对于高血压患者β受体阻滞剂可减少阿尔茨海默型脑损伤

2013-01-21 Susan Hughes CMT 吴君德 编译

  一项美国研究显示,对高血压患者,与其他降压药相比,用β受体阻滞剂降压与阿尔茨海默型脑损伤(神经纤维缠结及淀粉样斑块)较少有关。论文将在今年3月美国神经病学会年会上发布(摘要号2171)。   该结论来自火奴鲁鲁-亚洲衰老研究,该大规模研究对1991年时年龄为71~93岁的日裔美国人进行随访,每3年检查1次,并在其死后进行尸检。研究者对其中774例有或无痴呆临床表现的患者进行了脑部尸检。其中,

  一项美国研究显示,对高血压患者,与其他降压药相比,用β受体阻滞剂降压与阿尔茨海默型脑损伤(神经纤维缠结及淀粉样斑块)较少有关。论文将在今年3月美国神经病学会年会上发布(摘要号2171)。

  该结论来自火奴鲁鲁-亚洲衰老研究,该大规模研究对1991年时年龄为71~93岁的日裔美国人进行随访,每3年检查1次,并在其死后进行尸检。研究者对其中774例有或无痴呆临床表现的患者进行了脑部尸检。其中,610例患者有高血压,或者采用降压药物治疗。

  采用单药降压患者的药物包括β受体阻滞剂(40例)、血管紧张素转换酶抑制剂(ACEI,35例)、利尿剂(60例)、钙通道阻断剂(103例),以及血管舒张剂(13例)。对多药降压患者,43例联用β受体阻滞剂及其他降压药,46例联用其他降压药。

  结果,无高血压者阿尔茨海默型脑损伤最少;与不用药或用其他药物者相比,用β受体阻滞剂治疗的高血压患者阿尔茨海默型脑损伤较少,接近无高血压者,且其大脑小动脉梗死也较少;联用β受体阻滞剂及其他药物患者的脑部异常情况介于两者之间。

原文阅读:Beta-blockers linked to fewer Alzheimer's lesions

    

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    2013-03-23 zhyy88
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