预混胰岛素控制餐后血糖或优于基础胰岛素

2012-05-16 伊文 糖尿病手机报第12期

  美国一项研究表明,对口服降糖药(OAD)治疗无效的2型糖尿病患者,与基础胰岛素相比,启用预混胰岛素(每日2次)治疗可显著改善餐后血糖水平,还可减少晚期糖基化终末产物(AGE)前体产生。研究4月30日在线发表于《糖尿病及其并发症杂志》(J Diabetes Complications)。   该项开放标签单中心研究纳入14例OAD治疗血糖控制不佳的2型糖尿病患者,随机予以基

  美国一项研究表明,对口服降糖药(OAD)治疗无效的2型糖尿病患者,与基础胰岛素相比,启用预混胰岛素(每日2次)治疗可显著改善餐后血糖水平,还可减少晚期糖基化终末产物(AGE)前体产生。研究4月30日在线发表于《糖尿病及其并发症杂志》(J Diabetes Complications)。

  该项开放标签单中心研究纳入14例OAD治疗血糖控制不佳的2型糖尿病患者,随机予以基础胰岛素(甘精胰岛素每日1次)或预混胰岛素(赖脯胰岛素75/25,每日2次),12周后交换方案。结果显示,两种胰岛素治疗方案均能显著改善空腹血糖和HbA1c,但预混胰岛素组的平均餐后血糖显著低于基础胰岛素组(153 mg/dl对199 mg/dl),空腹和餐后3-脱氧葡糖醛酮(3-DG)水平均明显降低。



    

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    2013-04-16 baoya
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