J Thromb Haemost:绝经后妇女血管舒缩症状与静脉血栓形成的风险!

2018-03-05 xing.T MedSci原创

由此可见,尽管在发表的研究中血管舒缩症状与其他心血管事件的风险有关,但该研究的发现并不表明血管舒缩症状是VT风险的一个标志。

血管舒缩症状可能是心血管风险变化的标志,但目前尚不清楚这些症状是否与静脉血栓形成(VT)的风险有关。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在独立于潜在的解释变量来评估绝经后妇女血管运动症状的存在和严重程度与VT风险之间的关系。

这项队列研究纳入了妇女健康倡议(WHI)激素治疗试验(n=24508)和观察性研究(n=87783)的参与者。在基线时,妇女报告了是否有潮热或盗汗,如果有,需要报告严重程度。研究人员使用Cox比例风险模型估计了血管舒缩症状的存在和严重程度与VT风险之间的关系,调整潜在的变量:年龄、BMI、吸烟状况、种族/种族以及随时间变化的当前激素治疗的使用情况。

在基线时,WHI激素治疗试验参与者平均年龄为64岁,WHI观察研究参与者平均年龄为63岁。在WHI激素治疗试验中,中位数为8.2年的随访期间,522名妇女发生了VT事件。在WHI的观察性研究中,随访7.9年期间,1103名妇女发生了VT事件。在调整后的分析中,研究人员没有发现任何证据表明血管舒缩症状存在(风险比= 0.91 [ 95%可信区间:0.75-1.1 ]在WHI激素治疗试验;风险比= 1.1 [ 95%可信区间:0.99-1.3 ]在WHI观察性研究)或严重程度(重度与轻度相比的风险比= 0.99 [ 95%可信区间:0.53-1.9 ]在WHI激素治疗试验;风险比= 1.3 [ 95%可信区间:0.89-2 ]在WHI观察性研究)与VT发生的风险之间存在相关性。

由此可见,尽管在发表的研究中血管舒缩症状与其他心血管事件的风险有关,但该研究的发现并不表明血管舒缩症状是VT风险的一个标志。

原始出处:


L.B. Harrington,et al. Vasomotor symptoms and the risk of incident venous thrombosis in postmenopausal women.Journal of Thrombosis and Haemostasis.2018. http://onlinelibrary.wiley.com/doi/10.1111/jth.13993/full

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    2018-04-17 changfy
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href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Wed Mar 07 12:55:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293677, encodeId=a73b2936e771, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Wed Mar 07 00:42:22 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293388, encodeId=0c822933884e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Tue Mar 06 02:36:58 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-12 xue8602
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293388, encodeId=0c822933884e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Tue Mar 06 02:36:58 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293388, encodeId=0c822933884e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Tue Mar 06 02:36:58 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-07 zxxiang
  9. 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    2018-03-07 jihuaijun1112

    学习学习学习

    0

  10. 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    2018-03-06 121832a9m88暂无昵称

    学习了

    0

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