Bone：遗传对骨小梁评分的影响有多大？

2016-08-29 Moon 译 MedSci原创

本研究旨在评估骨小梁评分(TBS)变异的遗传影响程度。我们发现，遗传因素占45%的TBS变异，TBS和骨密度之间的共同变化部分由遗传因素决定。骨小梁评分(TBS)已成为脆性骨折的一个重要的预测因素，但TBS的个体差异尚未探究。在这项研究中，我们试图确定在一般人群中TBS评分变异的遗传贡献。这项研究包括556名妇女和189名男性，来自265个家庭。个人年龄36.7岁（SD 11）。我

本研究旨在评估骨小梁评分(TBS)变异的遗传影响程度。我们发现，遗传因素占45%的TBS变异，TBS和骨密度之间的共同变化部分由遗传因素决定。

骨小梁评分(TBS)已成为脆性骨折的一个重要的预测因素，但TBS的个体差异尚未探究。在这项研究中，我们试图确定在一般人群中TBS评分变异的遗传贡献。

这项研究包括556名妇女和189名男性，来自265个家庭。个人年龄36.7岁（SD 11）。我们测量腰椎骨密度(BMD; Hologic Horizon)，然后从BMD同一Hologic扫描处派生出TBS。使用生物模型将TBS的变异分为两部分：加性遗传因素和环境因素。估计遗传指数作为遗传因素所占总变异的比例。进行二元遗传分析估计TBS和BMD测量之间的遗传相关性。

数据显示，TBS与腰椎BMD显著相关(r=0.73; P<0.001)。平均TBS男性高于女性，在调整了年龄和身高后，两者TBS与腰椎BMD均显著相关。年龄和身高调整后的TBS遗传指数为0.46 (95% CI, 0.39-0.54)，与SBMD (0.44; 95% CI, 0.31-0.55)相差不大。此外，TBS和LSBMD之间的遗传相关性为0.35 (95% CI, 0.21-0.46)，TBS和股骨颈骨密度的遗传相关性为0.21 (95% CI, 0.10-0.33)。

大约45%的TBS差异受到传因素的影响，与对腰椎骨密度影响的大小是相似的。这一发现对特定的基因变异可能与TBS和骨折风险的相关性提供了理由。

原始出处：

Ho-Pham LT.et al.Genetic determinant of trabecular bone score (TBS) and bone mineral density: A bivariate analysis.Bone. 2016 Aug 20;92:79-84. doi: 10.1016/j.bone.2016.08.015. [Epub ahead of print]

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2017-02-16 limedical1974

#骨小梁#

28 0
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2016-11-24 apoenzyme

#Bone#

33 0
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2017-06-19 zhao4616

#骨小梁评分#

31 0
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2016-09-17 1e10c84am36(暂无匿称)

不错哦，会学到很多

60 0
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2016-09-07 李东泽

很好，不错，以后会多学习

1 0
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2016-09-03 doctorJiangchao

继续学习

54 0
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2016-09-03 doctorJiangchao

继续关注

57 0

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Bone：遗传对骨小梁评分的影响有多大？

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