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Eur Respir J：低分子肝素在肺癌患者中有抗肿瘤效果吗？

2018-10-05 xing.T MedSci原创

LMWH肺癌抗肿瘤
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由此可见，对于完全切除的I-IIIA期NSCLC患者，辅助性亭扎肝素治疗对总体和无复发生存率没有明显的影响。这些结果不支持LMWH作为抗肿瘤剂进行进一步临床评估。

尚未研究在早期癌症患者中检测肝素的抗肿瘤和抗转移特性。近日，呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章，该研究的目的是评估辅助低分子量肝素（LMWH）亭扎肝素是否影响切除的非小细胞肺癌（NSCLC）患者的存活率。

完全切除的I期、II期或IIIA期NSCLC患者被随机分配接受皮下注射亭扎肝素100 IU·kg-1，每天一次，持续12周，或者除标准治疗外不进行任何治疗。该试验是开放组别的研究，并且研究结果进行盲法集中评判。该研究的主要结局是总体生存率。

549例患者随机接受亭扎肝素（n=269）或对照（n=280）治疗，患者年龄平均±SD为61.6±8.9岁，190例（34.6％）患者为II-III期肿瘤患者，220例（40.1％）患者接受辅助化疗。中位随访时间为5.7年。组间总生存率无显著差异（风险比（HR）为1.24,95％CI为0.92-1.68; p=0.17）。组间肿瘤复发的累积发生率无差异（HR为0.94，95％CI为0.68-1.30; p=0.70）。

由此可见，对于完全切除的I-IIIA期NSCLC患者，辅助性亭扎肝素治疗对总体和无复发生存率没有明显的影响。这些结果不支持LMWH作为抗肿瘤剂进行进一步临床评估。

原始出处：

Guy Meyer,et al. Anti-tumour effect of low molecular weight heparin in localised lung cancer: a phase III clinical trial.chest.2018. http://erj.ersjournals.com/content/52/3/1800589

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    2019-09-20 gds2009

    #肺癌患者#

    0

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    2018-10-07 清风拂面

    谢谢分享学习

    0

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    2018-10-07 jingyanzhu715_39486103

    #低分子肝素#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1990661, encodeId=b5cd19906611a, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Fri Sep 20 22:57:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348324, encodeId=ac02348324a4, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Oct 07 09:02:57 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481456, encodeId=46c0148145616, content=<a href='/topic/show?id=cf432615e79' target=_blank style='color:#2F92EE;'>#低分子肝素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26157, encryptionId=cf432615e79, topicName=低分子肝素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=192e7793966, createdName=jingyanzhu715_39486103, createdTime=Sun Oct 07 03:57:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348054, encodeId=77383480542a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Fri Oct 05 17:44:51 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046636, encodeId=121f10466365b, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Oct 05 15:57:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348036, encodeId=a8ee3480360a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eiadcQaiaZ4fUvicZKEbibPBA2otZ0yzMeAVET5icsaS77W0Tvo3ibFMibzxTVRPsg62xJu0GicwBCvAlPMyu7TB6j86ug/132, createdBy=d64c1981665, createdName=一一一多, createdTime=Fri Oct 05 14:44:31 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348035, encodeId=0618348035ec, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Oct 05 13:52:19 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348030, encodeId=853634803034, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Oct 05 13:50:49 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348029, encodeId=e27b348029da, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Fri Oct 05 13:11:44 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-05 医者仁心5538

    学习了

    0

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    2018-10-05 CHANGE

    疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

    0

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    2018-10-05 一一一多

    学习学习

    0

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    2018-10-05 清风拂面

    谢谢分享学习

    0

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    2018-10-05 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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    2018-10-05 orangesking

    好

    0