Eye:眼部手术对Graves眼病患者血-房水屏障完整性的影响

2015-02-20 范伟 MedSci原创

目的 本研究分析了经历眼眶减压术,眼外肌,双眼皮手术后Graves眼病患者房水闪光的相关性。属于前瞻性介入病例系列。 患者和方法 27名(20名女性和7名男性,54.4岁±5.7)Graves眼病患者的48只眼接受手术治疗。9名(55.3岁±3.6)患者的18只眼接受眼眶减压术。11名(54.7岁±5.6)患者的19只眼接受眼外肌手术,7名(53.9岁±4.9)患者的13只眼接受双眼皮手

目的 本研究分析了经历眼眶减压术,眼外肌,双眼皮手术后Graves眼病患者房水闪光的相关性。属于前瞻性介入病例系列。
 
患者和方法 27名(20名女性和7名男性,54.4岁±5.7)Graves眼病患者的48只眼接受手术治疗。9名(55.3岁±3.6)患者的18只眼接受眼眶减压术。11名(54.7岁±5.6)患者的19只眼接受眼外肌手术,7名(53.9岁±4.9)患者的13只眼接受双眼皮手术,对照组(34名患者53.9岁±5.1)。激光光斑分析和临床评估于手术前,术后1天,7天,3个月进行。
 
结果 进行干预的Graves眼病患者的房水闪光(14.03±8.45)明显的比对照组(7.89±3.56)(P<0.001)要高,并与临床活动性评分及眼内压相关。进行眼眶减压术的患者,第一天闪光值从17.7± 10.63 PC/MS 增加到38.32±13.56 PC/MS,第7天到41.31±17.19 PC/MS ,3个月内恢复到16.01 ±8.58 PC/MS。进行眼外肌手术的患者,第一天闪光值从13.05±6.50增加到23.04±11.53 PC/MS(P<0.001),第七天返回到18.02±14.09 PC/MS 。双眼皮手术并没有改变闪光值。
 
结论 眼眶减压术破坏了血-房水屏障(BAB)。血-房水屏障的完整性在3个月内恢复到术前状态。眼外肌手术轻度的影响血-房水屏障的完整性,并在7日内影响消除。双眼皮手术不影响血-房水屏障。

原始出处
 
A Kłysik and M Kozakiewicz.Blood–aqueous barrier integrity in patients with Graves’ ophthalmopathy (GO), before and after rehabilitative surgery.Eye , (13 February 2015) | doi:10.1038/eye.2014.337.

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    2015-03-25 heli0118
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    2015-03-15 xinmeili
  5. [GetPortalCommentsPageByObjectIdResponse(id=2006712, encodeId=aaf02006e12e6, content=<a href='/topic/show?id=99ff45888bc' target=_blank style='color:#2F92EE;'>#完整性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45888, encryptionId=99ff45888bc, topicName=完整性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Sun Apr 19 06:37:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776041, encodeId=c1bd1e7604191, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Mar 25 09:37:00 CST 2015, time=2015-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029815, encodeId=501e202981594, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Jul 10 03:37:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039585, encodeId=eaea2039585b8, content=<a href='/topic/show?id=7ae88244a6' target=_blank style='color:#2F92EE;'>#Graves#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8244, encryptionId=7ae88244a6, topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Mar 15 21:37:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16737, encodeId=078a16e37ed, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Sun Feb 22 19:44:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515311, encodeId=541c15153118f, content=<a href='/topic/show?id=b3e18249d3' target=_blank style='color:#2F92EE;'>#Graves眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8249, encryptionId=b3e18249d3, topicName=Graves眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e2210763438, createdName=若水126, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540483, encodeId=0951154048331, content=<a href='/topic/show?id=fbbce2786cc' target=_blank style='color:#2F92EE;'>#眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72786, encryptionId=fbbce2786cc, topicName=眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b85c13256921, createdName=pps20023, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-02-22 MedSci客户端网友

    嗯嗯

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2006712, encodeId=aaf02006e12e6, content=<a href='/topic/show?id=99ff45888bc' target=_blank style='color:#2F92EE;'>#完整性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45888, encryptionId=99ff45888bc, topicName=完整性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Sun Apr 19 06:37:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776041, encodeId=c1bd1e7604191, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Mar 25 09:37:00 CST 2015, time=2015-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029815, encodeId=501e202981594, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Jul 10 03:37:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039585, encodeId=eaea2039585b8, content=<a href='/topic/show?id=7ae88244a6' target=_blank style='color:#2F92EE;'>#Graves#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8244, encryptionId=7ae88244a6, topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Mar 15 21:37:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16737, encodeId=078a16e37ed, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Sun Feb 22 19:44:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515311, encodeId=541c15153118f, content=<a href='/topic/show?id=b3e18249d3' target=_blank style='color:#2F92EE;'>#Graves眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8249, encryptionId=b3e18249d3, topicName=Graves眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e2210763438, createdName=若水126, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540483, encodeId=0951154048331, content=<a href='/topic/show?id=fbbce2786cc' target=_blank style='color:#2F92EE;'>#眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72786, encryptionId=fbbce2786cc, topicName=眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b85c13256921, createdName=pps20023, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2006712, encodeId=aaf02006e12e6, content=<a href='/topic/show?id=99ff45888bc' target=_blank style='color:#2F92EE;'>#完整性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45888, encryptionId=99ff45888bc, topicName=完整性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Sun Apr 19 06:37:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776041, encodeId=c1bd1e7604191, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Mar 25 09:37:00 CST 2015, time=2015-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029815, encodeId=501e202981594, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Jul 10 03:37:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039585, encodeId=eaea2039585b8, content=<a href='/topic/show?id=7ae88244a6' target=_blank style='color:#2F92EE;'>#Graves#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8244, encryptionId=7ae88244a6, topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Mar 15 21:37:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16737, encodeId=078a16e37ed, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Sun Feb 22 19:44:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515311, encodeId=541c15153118f, content=<a href='/topic/show?id=b3e18249d3' target=_blank style='color:#2F92EE;'>#Graves眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8249, encryptionId=b3e18249d3, topicName=Graves眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e2210763438, createdName=若水126, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540483, encodeId=0951154048331, content=<a href='/topic/show?id=fbbce2786cc' target=_blank style='color:#2F92EE;'>#眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72786, encryptionId=fbbce2786cc, topicName=眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b85c13256921, createdName=pps20023, createdTime=Sun Feb 22 13:37:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-02-22 pps20023