Heart:出生前暴露于饥荒与成人疾病风险

2019-11-11 xing.T MedSci原创

由此可见,该研究的结果表明出生前暴露于中国大饥荒可能会增加心血管疾病的风险,成年后的生活方式可能会改变这种风险。

为了全面评估出生前暴露于中国大饥荒的经历对中年人慢性病风险的潜在影响。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究纳入了来自中国嘉道理生物银行的92284名年龄在39-51岁之间的受试者,他们出生在饥荒时期,并且没有重大慢性疾病。

研究人员将参与者分为非饥荒出生者(1956年10月1日至1958年9月30日以及1962年10月1日至1964年9月30日)和饥荒时期出生者(1959年10月1日至1961年9月30日出生)。结局为心血管疾病、癌症和呼吸系统疾病。Cox回归用于评估饥荒暴露的调整后HR和95%CI。研究人员根据基线特征进行亚组分析。

在中位数为10.1年的随访期间,研究人员确定了4626例突发性缺血性心脏病(IHD)病例,7332例脑血管疾病例,3111例癌症病例和16081例呼吸系统疾病病例。在整个人群中,出生前暴露于饥荒与成年后患任何慢性疾病的风险没有统计学相关性。然而,对于城市参与者,与非饥荒时期出生者相比,饥荒期出生者具有更高的脑血管疾病风险(HR为1.18;95%CI为1.09至1.28);对于农村参与者,未发现这种关联(交互作用P<0.001)。此外,研究人员观察到体育锻炼水平较低的参与者的出生前饥荒暴露与IHD(HR为1.15; 95%CI为1.05至1.26)和脑血管疾病(HR为1.13; 95%CI为1.05至1.21)之间存在相关性,但在体育锻炼水平较高的参与者中则无关。

由此可见,该研究的结果表明出生前暴露于中国大饥荒可能会增加心血管疾病的风险,成年后的生活方式可能会改变这种风险。 

原始出处:

Ruogu Meng.et al.Early famine exposure and adult disease risk based on a 10-year prospective study of Chinese adults.heart.2019.http://dx.doi.org/10.1136/heartjnl-2019-315750

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    2019-11-13 zhaojie88
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    2019-11-13 slcumt
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    2019-11-12 qingfengqishi5

    学习了,学习了

    0