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Aging：SATB2-Nanog轴与颅面骨的间充质干细胞的年龄相关的内在变化相关联

2019-04-27 不详 网络

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骨髓间充质干细胞（BMSCs）衰老导致与年龄相关的骨丧失。颌骨中的牙槽骨起源于神经嵴细胞，具有明显的位点和年龄相关特性。然而，来自牙槽骨（AB-BMSC）的BMSC的这种内在特征和潜在的调节机制仍然是未知的。本研究中，我们发现人类AB-BMSCs中特殊的富含AT的结合蛋白2（SATB2）的表达随着衰老而显着降低。来自年轻供体的AB-BMSC的SATB2敲低显示了这些与体外老化相关的表型。同时，强制

骨髓间充质干细胞（BMSCs）衰老导致与年龄相关的骨丧失。颌骨中的牙槽骨起源于神经嵴细胞，具有明显的位点和年龄相关特性。然而，来自牙槽骨（AB-BMSC）的BMSC的这种内在特征和潜在的调节机制仍然是未知的。

本研究中，我们发现人类AB-BMSCs中特殊的富含AT的结合蛋白2（SATB2）的表达随着衰老而显着降低。来自年轻供体的AB-BMSC的SATB2敲低显示了这些与体外老化相关的表型。同时，强制性SATB2过表达可以使老年供体的AB-BMSCs恢复活力。重要的是，satb2基因修饰的BMSCs治疗可以预防大鼠衰老过程中牙槽骨的丢失。机制上，干细胞调节剂Nanog被鉴定为BMSC中SATB2的直接转录靶，并且起到SATB2的下游介质的作用。

总的来说，我们的数据显示AB-BMSCs中的SATB2与其年龄相关的特性相关，并且通过维持Nanog表达来防止AB-BMSC衰老。这些发现强调了基于转录因子的细胞重编程对抗衰老疗法的转化潜力。

原始出处：

Peipei Zhou, Geng Wu, et al., SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone. Aging (Albany NY). 2016 Sep; 8(9): 2006–2019.

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#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1933462, encodeId=937219334623f, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sun Apr 05 04:18:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028041, encodeId=59d02028041e8, content=<a href='/topic/show?id=384e12502a2' target=_blank style='color:#2F92EE;'>#NANOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12502, encryptionId=384e12502a2, topicName=NANOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Aug 16 16:18:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815487, encodeId=df44181548e03, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Feb 15 04:18:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2020-04-05 lily1616

    #年龄相关#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1933462, encodeId=937219334623f, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sun Apr 05 04:18:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028041, encodeId=59d02028041e8, content=<a href='/topic/show?id=384e12502a2' target=_blank style='color:#2F92EE;'>#NANOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12502, encryptionId=384e12502a2, topicName=NANOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Aug 16 16:18:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815487, encodeId=df44181548e03, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Feb 15 04:18:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2019-08-16 heli0118

    #NANOG#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1933462, encodeId=937219334623f, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sun Apr 05 04:18:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028041, encodeId=59d02028041e8, content=<a href='/topic/show?id=384e12502a2' target=_blank style='color:#2F92EE;'>#NANOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12502, encryptionId=384e12502a2, topicName=NANOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Aug 16 16:18:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815487, encodeId=df44181548e03, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Feb 15 04:18:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2020-02-15 h.y200607_23674418

    #间充质干细#

    0