Int J Cardiol:更优他汀类药物治疗患者血脂紊乱的相关危险因素分析!

2017-07-02 xing.T MedSci原创

由此可见,在接受最佳他汀类药物治疗的中国患者中的AD的患病率很高。与AD相关的一些危险因素已经被确定,但根据两个标准/指南,这些因素略有不同。他汀类药物治疗的强度并没有降低AD的患病率,联合降脂治疗可能更适合中国患者。

近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,这项研究旨在调查中国门诊患者致动脉粥样化的血脂异常(AD)患病率,这些患者采用他汀类药物单药治疗低密度脂蛋白胆固醇(LDL-C)水平达到目标范围,并评价这些患者的特点。

血脂异常的国际调查的中国研究是在中国122家医院进行分析的。在LDL-C达到目标范围的患者中,AD被定义为甘油三酯水平≥1.7mmol/L和/或低水平的高密度脂蛋白胆固醇(男性<1mmol/L;女性:<1.3mmol/L)。

研究人员对22039例接受他汀类单药治疗的患者进行了分析。根据美国国家胆固醇教育计划成人治疗组III,13088例患者LDL-C水平达到目标范围,并且其中7134例患者存在AD。年龄、男性、体重指数、久坐不动的生活方式、糖尿病、缺血性脑血管病、血清尿酸水平与空腹血糖(P均<0.05)与AD独立相关。基于中国血脂异常治疗指南,13551例患者LDL-C水平达到了目标范围,并且其中有7719例患者存在AD。 年龄、男性、体重指数、久坐不动的生活方式、冠心病、血清尿酸水平与空腹血糖(P均<0.05)与AD独立相关,他汀类药物的治疗强度不会影响AD的患病率。

由此可见,在接受最佳他汀类药物治疗的中国患者中的AD的患病率很高。与AD相关的一些危险因素已经被确定,但根据两个标准/指南,这些因素略有不同。他汀类药物治疗的强度并没有降低AD的患病率,联合降脂治疗可能更适合中国患者。

原始出处:


Wang Zhaoa, et al. Risk factors associated with atherogenic dyslipidemia in the presence of optimal statin therapy. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2017.06.105

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 07 07:42:33 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218078, encodeId=d5152180e802, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Jul 03 09:44:51 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-25 jyzxjiangqin

    他汀对高脂的治疗。

    0

  5. 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    2017-07-21 1e10c84am36(暂无匿称)

    文章不错,谢谢分享

    0

  6. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 07 07:42:33 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218078, encodeId=d5152180e802, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Jul 03 09:44:51 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-15 jyzxjiangqin

    他汀类药物治疗。

    0

  7. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 07 07:42:33 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218078, encodeId=d5152180e802, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Jul 03 09:44:51 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-13 1e10c84am36(暂无匿称)

    文章真好,拜读了

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 07 07:42:33 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218078, encodeId=d5152180e802, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Jul 03 09:44:51 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-08 周周人

    学习。

    0

  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 07 07:42:33 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218078, encodeId=d5152180e802, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Jul 03 09:44:51 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-07 jyzxjiangqin

    他汀药物治疗的危险因素分析。

    0

  10. 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    2017-07-03 明天会更好!

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