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NRR：丁基苯酞（恩必复）可治疗弥漫性脑损伤

2013-11-28 EurekAlert EurekAlert

丁基苯酞恩必复
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DL-3N丁基苯酞已被初步证明可有效治疗脑损伤，但其对弥漫性脑损伤后微循环障碍的作用目前还不清楚。【原文下载】 中国河北联合大学附属医院的李建民教授领导的团队为探讨dl-3n丁基苯酞对弥漫性脑损伤的脑保护作用，进行了一项研究。实验建立大鼠弥漫性脑损伤模型，然后立即腹腔注射dl-3n丁基苯酞（低剂量80mg/kg，高剂量160mg/kg）。 结果发现dl-3n丁基苯酞可以减轻脑超微结构的损伤程度

DL-3N丁基苯酞已被初步证明可有效治疗脑损伤，但其对弥漫性脑损伤后微循环障碍的作用目前还不清楚。【原文下载】

中国河北联合大学附属医院的李建民教授领导的团队为探讨dl-3n丁基苯酞对弥漫性脑损伤的脑保护作用，进行了一项研究。实验建立大鼠弥漫性脑损伤模型，然后立即腹腔注射dl-3n丁基苯酞（低剂量80mg/kg，高剂量160mg/kg）。

结果发现dl-3n丁基苯酞可以减轻脑超微结构的损伤程度，减轻血脑屏障通透性和脑水肿，同时增加血管密度和脑血流量，以及改善运动和感觉功能。说明，dl-3n丁基苯酞可能通过改善微循环障碍，减轻血脑屏障损伤和脑水肿，对弥漫性脑损伤产生保护作用。

原文出处

Yaning Zhao，Jianmin Li，Pan Zhang，Changxiang Chen，Shuxing Li.Protective effects of dl-3n-butylphthalide against diffuse brain injury .Neural Regeneration Research. 2013, (28)【原文下载】

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1396797, encodeId=ad4d1396e97bf, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438556, encodeId=ca331438556db, content=<a href='/topic/show?id=9851500416c' target=_blank style='color:#2F92EE;'>#弥漫性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50041, encryptionId=9851500416c, topicName=弥漫性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6308, encodeId=e8b063082f, content=很好，国药的经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd0690593, createdName=binhlv, createdTime=Fri Nov 29 11:52:00 CST 2013, time=2013-11-29, status=1, ipAttribution=)]
    2013-11-30 智者为医08

    #损伤#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1396797, encodeId=ad4d1396e97bf, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438556, encodeId=ca331438556db, content=<a href='/topic/show?id=9851500416c' target=_blank style='color:#2F92EE;'>#弥漫性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50041, encryptionId=9851500416c, topicName=弥漫性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6308, encodeId=e8b063082f, content=很好，国药的经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd0690593, createdName=binhlv, createdTime=Fri Nov 29 11:52:00 CST 2013, time=2013-11-29, status=1, ipAttribution=)]
    2013-11-30 zhouqu_8

    #弥漫性#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1396797, encodeId=ad4d1396e97bf, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438556, encodeId=ca331438556db, content=<a href='/topic/show?id=9851500416c' target=_blank style='color:#2F92EE;'>#弥漫性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50041, encryptionId=9851500416c, topicName=弥漫性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Nov 30 08:16:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6308, encodeId=e8b063082f, content=很好，国药的经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd0690593, createdName=binhlv, createdTime=Fri Nov 29 11:52:00 CST 2013, time=2013-11-29, status=1, ipAttribution=)]
    2013-11-29 binhlv

    很好，国药的经典

    0