Hypertension:警惕重金属污染!尿液重金属水平会影响血压纵向变化

2021-06-25 MedSci原创 MedSci原创

暴露于重金属可能会加速中年妇女的血压升高。

 “重金属这个术语较笼统。这关系到元素周期表,并指的是高密度或具有金属特性的各种元素。这些元素能在自然环境中找到,且也被工业用于制造大量的常见的产品。其中的一些例如铁,铜,硒,钼,锌,在微量时是身体所需的并维持正常功能,但在稍高的水平即有毒性

任何一种重金属的高浓度都可以刺激或破坏人类,污染土壤、空气、食物和水,并且可以长期存在于环境中,是潜在危害的来源,重金属这个术语经常被替换为“有毒金属”。而一个人表现出来的体征和症状取决于金属的种类、结构、数量、暴露的时间长度、暴露的方式、该人的年龄以及他们大致的健康状况。

重金属检测组合是一组测定特定的、潜在有毒的金属的量的测试组合,它们存在于血液,尿液或极少地在头发或身体其他组织或液体中。最常见包括铅、汞和砷,其他可能包括镉、铜、和锌等。


大家都知道,重金属不仅会造成环境危害,还会影响人体全身各系统和器官。例如,食入汞后直接沉入肝脏,对大脑、神经、视力破坏极大。天然水每升水中含0.01毫克,就会导致人中毒。

既往的研究表明,重金属的环境暴露还可能会导致血压升高。其中,女性比男性的心脑血管疾病风险更大,然而,目前来自中年妇女的证据是有限的。为此,来自美国密歇根大学流行病学专家在全国妇女健康多污染物研究中评估了尿液中砷、镉、汞和铅浓度与血压纵向变化的关系。

样本包括1317名白人、黑人、华人和日本妇女,基线年龄为4556岁(1999-2000年),所有参与者每年或每两年测量一次收缩压(SBP)和舒张压(DBP)。在基线时测定了尿液中的金属浓度。SBPDBP的纵向变化按金属浓度的分位数使用线性混合效应模型进行建模。

经过多变量调整,估计最高和最低四分位数的SBP年化增长(95%CI),砷为0.93(0.85-1.01)mmHg和0.74(0.66-0.82)mmHg,汞为0.82(0.75-0.90)mmHg和0.72(0.65-0.80)mmHg,而铅为0.86(0.78-0.93)mmHg和0.72(0.64-0.79)mmHg在砷、汞、铅与DBP的关系方面也观察到类似的结果。

只有在从不吸烟的人中,尿液中的镉与更大的SBP上升率有关。与浓度较低的妇女相比,所有四种金属浓度较高的妇女的SBPDBP的年增长率更大。

 综上,暴露于重金属可能会加速中年妇女的血压升高。

 

参考文献:

Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation. https://doi.org/10.1161/HYPERTENSIONAHA.121.17295Hypertension. ;0:HYPERTENSIONAHA.121.17295

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    2022-02-08 feather89
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    2021-10-30 saikp
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