Brain Injury:抗胆碱能药物增加脑损伤患者住院时长

2015-08-11 MedSci 译 MedSci原创

大家都知道抗胆碱能药物的副作用包括:暂时性认知障碍,意识错乱和眩晕。但由英国东安格利亚大学(UEA)研究人员研究后发现抗胆碱能药物会影响脑损伤患者的脑功能恢复,是第一个专注于该项目的研究。来自阿斯顿大学、其他研究中心和英国国家卫生局的科学家在 这项研究中调查了52名患有脑损伤或脊髓损伤且正在接受神经康复治疗的患者。这些病人经常使用抗胆碱能药物来缓解疼痛,解决尿失禁和其他问题。研究人员发现,长期服用

大家都知道抗胆碱能药物的副作用包括:暂时性认知障碍,意识错乱和眩晕。但由英国东安格利亚大学(UEA)研究人员研究后发现抗胆碱能药物会影响脑损伤患者的脑功能恢复,这是第一个专注于该项目的研究。


来自阿斯顿大学、其他研究中心和英国国家卫生局的科学家在这项研究中调查了52名患有脑损伤或脊髓损伤且正在接受神经康复治疗的患者。这些病人经常使用抗胆碱能药物来缓解疼痛,解决尿失禁和其他问题。研究人员发现,长期服用大剂量抗胆碱能药物(ACB)的患者平均住院时间要更长一些。经分析表明,患者服用ACB的剂量与时长与他们的住院时长有关系,服用ACB多且久的患者平均住院时间较长。但是这仅能表示二者表现出这一关联,并不能起绝对的证明作用。

英国诺里奇的东安格利亚大学医学院临床精神病学教授Chris Fox认为,研究人员需要进行更多的研究以确定这种关联是否真的可以证实,并且需要证明ACB药物对处于恢复期的患者的影响。他解释道,这是ACB在治疗脑损伤和脊髓损伤过程中表现出的药物副作用,这些副作用会不同程度地影响患者的神经恢复时长。

因此研究人员认为,医生需要切实考虑病人的病情,判断使用ACB药物是否必须及其合适剂量,最大限度地促使患者神经功能恢复的同时又可减少患者住院时长,提高医疗效率。

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    2016-01-04 xuqianhua
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    2015-08-13 grace5704
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