Pain:脑干三叉神经纤维微结构异常与三叉神经痛各亚型的治疗反应有关

2021-06-28 MedSci原创 MedSci原创

这些新的发现证明了DTI作为一种客观、无创的治疗反应预测工具的价值,并阐明了TN人群中治疗反应者和无反应者的区别。

三叉神经痛(TN)的神经外科治疗可以持久缓解疼痛;然而,一些患者没有反应,需要进行多次重复的手术。手术结果可能因TN的类型而异,但原因尚不清楚。TN的神经影像学研究提示三叉神经脑干纤维异常;然而,这是否是不同亚型TN治疗无反应的共同特征尚不清楚。 Mojgan Hodaie等在使用弥散张量成像(DTI)来确定脑干三叉神经纤维微结构是否是TN手术反应的常见生物标志物,以及这些异常的程度是否与跨亚型TN反应的可能性相关。研究成果发表在Pain杂志。 研究了98例接受神经外科治疗的TN患者(61例经典型TN,26例继发于多发性硬化,11例伴有孤立性桥脑病变)和50例健康对照。通过疼痛强度测量来评估治疗反应,并通过提取三叉神经近侧桥段的治疗前DTI指标来检查显微结构特征。 三叉神经多传感器扩散束成像及ROI定位。面板代表2例受试者的三叉神经束造影(白色)和近端脑桥节段的ROI放置(红色)。纤维束叠加在共同登记的半透明T1加权解剖和基础扩散张量图像上。扩散张量图像按方向着色(红色,左-右;绿色,前-后;蓝色,上-下)(左图)箭头表示三叉神经的根进入区,在那里纤维束造影是从(右图)支架表示脑干三叉

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    2021-06-30 贵阳
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    2021-06-28 沈楠

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