J Clin Endocrinol Metab:亚临床甲状腺功能亢进症增加痴呆风险

2016-10-05 Mechront 译 MedSci原创

根据最近公布的调查结果显示,亚临床甲状腺功能亢进症的成年人,患痴呆症的风险增加;且患者的简易精神状态检查表(MMSE)评分也会随着时间的推移而迅速下降。 来自瑞士伯尔尼大学医院的Nicolas Rodondi博士和同事对来自11项前瞻性队列研究、涉及16,805名参与者、中位随访时间44.4个月的数据进行了分析研究,探究痴呆和认知能力下降风险与亚临床甲状腺机能异常之间的关系。 数据显示

根据最近公布的调查结果显示,亚临床甲状腺功能亢进症的成年人,患痴呆症的风险增加;且患者的简易精神状态检查表(MMSE)评分也会随着时间的推移而迅速下降。

来自瑞士伯尔尼大学医院的Nicolas Rodondi博士和同事对来自11项前瞻性队列研究、涉及16,805名参与者、中位随访时间44.4个月的数据进行了分析研究,探究痴呆和认知能力下降风险与亚临床甲状腺机能异常之间的关系。

数据显示,与甲状腺功能正常者相比,亚临床甲状腺功能亢进患者的痴呆风险合并后RR值为1.67 (95% CI, 1.04-2.69);合并后阿尔茨海默病的RR值为1.67 (95% CI, 0.79-3.51)。

与甲状腺功能正常者相比,亚临床甲减患者的痴呆风险合并后RR值为1.14 (95% CI, 0.84-1.55);合并后阿尔茨海默病的RR值为0.95 (95% CI, 0.52-1.71)。

从基线开始,亚临床甲状腺功能亢进症患者的MMSE每年下降0.01(认知功能下降);不过对于亚临床甲状腺功能减退和甲状腺功能正常的参与者,变化相似。

研究者称:我们的系统评价和荟萃分析表明,与老年痴呆症风险增高的因素是亚临床甲状腺功能亢进症,而不是亚临床甲状腺功能减退症。

原始出处:

Dementia risk increases in adults with subclinical hypothyroidism.Helaio.October 4, 2016

Rieben C, et al. Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.J Clin Endocrinol Metab. 2016;doi:10.1210/jc.2016-2129.

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    2016-12-07 guojianrong
  2. 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    2016-12-10 一闲
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    2016-10-12 1e10c84am36(暂无匿称)

    好文章,受益

    0

  4. 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createdName=一闲, createdTime=Sat Dec 10 10:36:00 CST 2016, time=2016-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146368, encodeId=2a1b1463681a, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Oct 12 09:40:00 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146129, encodeId=b5731461296f, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:42:08 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146128, encodeId=96061461284b, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:42:02 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273714, encodeId=f71312e371483, content=<a href='/topic/show?id=10a5698555f' target=_blank style='color:#2F92EE;'>#甲状腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69856, encryptionId=1ba1698568b, topicName=甲状腺功能亢进症)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Oct 07 06:36:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140471, encodeId=a1961404e1dd, content=学习了,了解了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Wed Oct 05 16:54:57 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140407, encodeId=74bc14040ecd, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 15:41:39 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-11 知难而进

    继续关注!

    0

  5. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:42:08 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146128, encodeId=96061461284b, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:42:02 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273714, encodeId=f71312e371483, content=<a href='/topic/show?id=10a5698555f' target=_blank style='color:#2F92EE;'>#甲状腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, 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createdTime=Wed Oct 05 16:54:57 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140407, encodeId=74bc14040ecd, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 15:41:39 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-11 知难而进

    谢谢分享!

    0

  6. 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  7. 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  8. 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  9. 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createdTime=Wed Oct 05 16:54:57 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140407, encodeId=74bc14040ecd, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 15:41:39 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 186****0580(小山羊)

    学习了,了解了!

    0

  10. 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createdTime=Wed Oct 05 16:54:57 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140407, encodeId=74bc14040ecd, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 15:41:39 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 1e0d99ddm02(暂无匿称)

    总结的很好!

    0