Int J Oral Max Surg:颌下腺肿瘤的病理多样性和预后

2018-10-07 MedSci MedSci原创

颌下腺肿瘤是相对不常见的肿瘤,并且表现出不同的组织学类型和不同的预后。本研究的目的是分析6年(2009年1月至2015年12月)间颌下腺恶性肿瘤的病例。

颌下腺肿瘤是相对不常见的肿瘤,并且表现出不同的组织学类型和不同的预后。本研究的目的是分析6年(2009年1月至2015年12月)间颌下腺恶性肿瘤的病例。

回顾性分析了6年期间患者的数据,纳入了51例颌下腺恶性肿瘤患者。记录人口统计学数据,临床病理学细节,接受的治疗,并发症和随访。 51名患者的平均年龄为49.1岁。随访平均20.3个月。

47例患者中有9例(19.1%)在随访期间发生远处转移,只有3例(6.4%)发生局部复发。 2年无病生存率为69.7%,2年末总生存率为77.8%。当考虑所有亚型时,5年精确生存率为57.8%。复发的总体平均时间为10个月(6-24个月)。

在多变量分析中,淋巴结阳性是唯一具有显着意义的预后因素,而年龄,性别,神经周围浸润和分级则不是。随着外科和放射治疗技术的进步,局部控制率大大提高;然而,仍然缺乏有效的预防全身复发的辅助治疗手段。

原始出处:

S.K.Rajappa, et al.A gland of diverse pathology and unpredictable behaviour: our experience of primary submandibular gland malignancies. International Journal of Oral and Maxillofacial Surgery.2018 October. Doi:10.1016/j.ijom.2018.05.012

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