Lancet:慢性骨髓增殖性肿瘤和新发癌症的患者的生存

2015-06-13 崔倩 译 MedSci原创

背景:慢性骨髓增殖性肿瘤患者在新的实体或血液系统肿瘤的风险增加,但前骨髓增值性肿瘤患者的预后情况目前还不清楚。    方法:研究人员使用丹麦1980至2011年的医疗数据库中的数据,比较了有或没有前期诊断的骨髓增殖性肿瘤患者的生存率、并对年龄、性别、诊断年份、以及癌症类型。研究人员评估的结果是癌症分期和并发症。    结果:相比较于515

背景:慢性骨髓增殖性肿瘤患者在新的实体或血液系统肿瘤的风险增加,但前骨髓增值性肿瘤患者的预后情况目前还不清楚。
    
方法:研究人员使用丹麦1980至2011年的医疗数据库中的数据,比较了有或没有前期诊断的骨髓增殖性肿瘤患者的生存率、并对年龄、性别、诊断年份、以及癌症类型。研究人员评估的结果是癌症分期和并发症。
    
结果:相比较于5155例无骨髓增殖性肿瘤历史的患者,1246例有骨髓增殖性肿瘤历史的患者的数据可用。在有新的局部实体肿瘤的患者中,对于前期患有原发性血小板增多症的患者的5年生存率为49.8%(95%Cl 39.1-59.6),前期患有真性红细胞增多症的患者的为47.9%(42.1-53.4),前期患有慢性骨髓性白血病的患者的为48.0%(34.1-60.7)。在没有前骨髓增殖性肿瘤的患者中,以上三种肿瘤的5年生存率分别为72.4%(68.4-76.0),63.9%(61.5-66.2),和74.3%(68.2-79.4)。实体瘤和前期有骨髓增生性肿瘤的患者的死亡风险比无骨髓增生性肿瘤的患者高1.21-2.28倍。超额死亡风险的观察没有考虑新发癌症骨髓增生性肿瘤是否在5年或5年以上诊断的。
    
结论:前期有骨髓增殖性肿瘤预示着新的原发癌患者的不佳预后。

原始出处:

Dr Henrik Frederiksen,Dóra Körmendiné Farkas,Christian Fynbo Christiansen,homas Stauffer Larsen,et al.Survival of patients with chronic myeloproliferative neoplasms and new primary cancers,Lancet,2015.6.11

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    2015-06-26 howi
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    2015-06-25 huaxipanxing

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