Int J Cardiol:非高密度脂蛋白胆固醇与冠心病的死亡率相关

2016-07-18 phylis 译 MedSci原创

背景:非高密度脂蛋白(HDL)的胆固醇水平,一般不受空腹状态或血清甘油三酯水平的影响,可能有助于预测未来的心血管事件。本研究旨在探讨一般日本人群中,非高密度脂蛋白胆固醇在致命性冠状动脉事件和卒中的发展中的作用。方法:从NIPPON DATA 90个前瞻性队列研究中,从1990对8383名受试者随访20年。排除无血脂或协变量数据者666例,561例75岁以上,274例心血管疾病史,181例有降脂治疗

背景:非高密度脂蛋白(HDL)的胆固醇水平,一般不受空腹状态或血清甘油三酯水平的影响,可能有助于预测未来的心血管事件。本研究旨在探讨一般日本人群中,非高密度脂蛋白胆固醇在致命性冠状动脉事件和卒中的发展中的作用。

方法:从NIPPON DATA 90个前瞻性队列研究中,从1990年对8383名受试者随访20年。排除无血脂或协变量数据者666例,561例75岁以上,274例心血管疾病史,181例有降脂治疗,6701名受试者纳入这一分析卒中死亡。

结果:在这期间,69名受试者死于冠心病和112例死于卒中。校正年龄和性别后,与非高密度脂蛋白胆固醇水平<3.9mmol/l的参与者相比,非HDL胆固醇水平3.9-4.3mmol/l,4.4-4.8mmol/l和≥4.9mmol/l冠心病死亡率的危险比分别为1.27(95% CI  0.65-2.49)、1.81(95% CI 0.92-3.55)和2.40(95% CI 1.30-4.43)。即使校正其他心血管疾病的危险因素时,相关性仍存在。非高密度脂蛋白胆固醇水平与卒中死亡率没有相关性。

结论:在一般的日本人群中,非高密度脂蛋白胆固醇水平与冠状动脉心脏疾病的未来死亡率明显相关,但不与卒中的死亡率相关。

原始出处:

Ito T, Arima H,et al. Relationship between non-high-density lipoprotein cholesterol and the long-term mortality of cardiovascular diseases: NIPPON DATA 90. Int J Cardiol. 2016 Jun 15


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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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    2016-08-04 cjingjuan

    目前研究不多

    0

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    2016-07-19 4546wk

    文章不错

    0

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    2016-07-19 医路开来

    很好的研究,学习啦

    0

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    2016-07-19 嗣嗣

    谢谢啦!受教……

    0

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