J Endod:MTA促进人牙周膜再生成功的首例临床证据

2017-03-25 MedSci MedSci原创

这篇报道是为了验证MTA在应用于人牙髓治疗过程中,是否能像在动物模型中一样,可以促进根尖周组织的再生。

这篇报道是为了验证MTA在应用于人牙髓治疗过程中,是否能像在动物模型中一样,可以促进根尖周组织的再生。

在家庭诊所内,研究者对患者的4颗牙齿使用MTA实施根管治疗,随后这4颗牙齿在治愈后以非治疗失败的其他原因拔除并进行观察。所有拔除的牙齿进行组织学处理,随后观察和分析根尖周结构对MTA的组织学反应,其中一颗牙齿进行免疫组织化学分析。

结果显示,在拔除前,所有实施MTA治疗过的牙齿通过临床和放射线检查,均显示根尖愈合的体征。通过组织学观察发现,所有牙齿至少在MTA表面形成一层类似于牙骨质样结构。不仅如此,通过免疫荧光双标观察I型和III型胶原的表达以及表达重叠区域,发现有呈纤维状、类似于牙周膜样的组织形成。

结论:MTA促进人牙周膜的组织愈合符合在动物实验中发现的愈合模式。研究发现,MTA能够促使其表面形成牙骨质样结构,表明MTA可以促进牙周膜再生。

原始出处:

Bartols A Dr, Roussa E, et al. First Evidence for Regeneration of the Periodontium to Mineral Trioxide Aggregate in Human Teeth. J Endod. 2017 Mar 18. pii: S0099-2399(17)30006-7. doi: 10.1016/j.joen.2016.12.027.

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    2017-12-16 xqptu
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    2017-04-05 山丫

    M丅A总让牙体医生惊喜又感叹!

    0

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    2017-03-26 liuxiaona
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