ESC2018丨 画钟测试可提前发现高血压患者痴呆风险

2018-09-01 马晨 中国科学报

8月25日至29日,2018年欧洲心脏病学会年会(ESC2018)在德国慕尼黑召开。会议报告中指出,高血压患者应定期进行认知功能障碍的画钟测试。

8月25日至29日,2018年欧洲心脏病学会年会(ESC2018)在德国慕尼黑召开。会议报告中指出,高血压患者应定期进行认知功能障碍的画钟测试。

研究发现,认知功能受损的高血压患者在5年内患有痴呆症的风险会逐渐增加。虽然这两种疾病的关联早已众所周知,但是在患有高血压的病人中并没有进行认知功能的常规测试。

阿根廷布宜诺斯艾利斯血管研究中心的Augusto Vicario博士在报告中指出,“选择特定时间要求患者在表盘中画出的实验,是一种检查高血压患者是否存在认知障碍的简便方法,同时也为医生在患者痴呆症发生之前提供了干预机会”。

通过与之前的简易精神状态检查(MMSE)方式相对比,阿根廷心脑疾病研究中心采用了画钟测试的方式检测了来自于阿根廷18个心脑疾病中心招募的1414名患有认知功能障碍的高血压患者。这些受试者平均年龄为60岁左右,其中62%的受试者为女性,其平均血压为144/84 mmHg。

在画钟测试中,研究者分发给每名患者一张上面画有一个直径为10厘米圆圈的白纸。他们首先将时钟的时刻编号写在圆圈的正确位置上,然后根据要求在“时钟”上画出规定时间3点40。研究者根据最终的画钟测试结果,将患者分为拥有正常、中度或者重度的认知障碍症。然而,简易精神状态检查(MMSE)是通过回答满分为30分的11个问题,之后根据分数将患者分为拥有正常(24~30)、中度(19~23)或重度(0~17)的认知障碍症。

研究人员发现,与简易精神状态检查(MMSE)方式相比,通过画钟测试的患有重度认知障碍的高血压患者要比前者检出率高出15个百分点。1/3在简易精神状态检查(MMSE)中被认知正常的患者却在画钟测试中结果异常,尤其是在中老年患者中的差异更为明显。

Augusto Vicario博士指出,“如果高血压不进行治疗,长期之后会逐渐损害大脑皮质下的动脉,并阻止皮层下和额叶之间的通信。这种脱节会导致‘执行功能’受损,例如视觉空间、细节记忆、计划、决策等能力。然后,画钟测试可以用来检测与这些执行功能相关的能力,但是简易精神状态检查(MMSE)只是检测其他几种认知能力,而与执行功能相关能力无关”。

此项研究还发现,画钟测试的结果可用于检测大脑中无声血管损伤的依据,并可以用于确定高血压患者患有痴呆症的风险指数。通过画钟测试还发现有超过1/3的患者患有痴呆症的风险指数极高。

最后,Augusto Vicario博士根据研究总结,画钟测试可以作为高血压患者认知能力下降的常规筛查工具,但同时也需要进一步研究以确定降低血压是否可以预防痴呆症的恶发。

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    2019-08-14 neurowu
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    2018-09-01 junJUN

    老年人痴呆何药可用??

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1785793, encodeId=dc4f1e8579373, content=<a href='/topic/show?id=1cb16995e7' target=_blank style='color:#2F92EE;'>#ESC2018#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6995, encryptionId=1cb16995e7, topicName=ESC2018)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Wed Aug 14 06:14:00 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798750, encodeId=a85b1e987500e, content=<a href='/topic/show?id=e83ce0289ee' target=_blank style='color:#2F92EE;'>#画钟测试#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70289, encryptionId=e83ce0289ee, topicName=画钟测试)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri May 17 22:14:00 CST 2019, time=2019-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316712, encodeId=830b1316e125b, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Mon Sep 03 07:14:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448259, encodeId=1a8a1448259ee, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Mon Sep 03 07:14:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048493, encodeId=14a210484937d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sat Sep 01 19:14:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342127, encodeId=6b8834212e10, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sat Sep 01 16:53:17 CST 2018, time=2018-09-01, status=1, ipAttribution=)]
    2018-09-01 orangesking

    看看

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