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Clinica Chimica Acta：MALDI-TOF质谱分析将daratumumab与m蛋白区分开来

2019-08-08 Gladiator MedSci原创

M蛋白
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<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size: 14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;;mso-fareast-font-family:宋体; mso-bidi-font-family:&quot;Times New Roman&qu

Daratumumab是一种治疗性IgG kappa单克隆抗体，它会对常规用于监测单克隆gammies患者的电泳检测造成假阳性干扰。在本研究中，研究人员评估了基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)对daratumumab与疾病相关的IgG kappa单克隆蛋白(m蛋白)的鉴别能力。

研究人员收集31例接受daratumumab治疗并有IgG kappa单克隆gammopathy病史的患者的临床废弃物标本。从血清中纯化免疫球蛋白，用MALDI-TOF法对其进行质谱分析。对于在daratumumab的预期m/z附近只鉴定出一个单克隆峰的样品，通过Hydrashift 2/4 daratumumab实验来确认m蛋白的存在。

利用MALDI-TOF质谱， daratumumab与m蛋白的鉴别率为84%（31个样品中共26个可被鉴别）。来自2个样品的结果是不确定的，因为通过Hydrashift测定未检测到M蛋白，并且MALDI-TOF MS也可能检测不到。 相比之下，daratumumab通过免疫固定可以区分31个样本中的14个（45％）中的M蛋白。

研究表明，与免疫固定相比，MALDI-TOF MS在区分daratumumab和m蛋白方面具有更高的特异性。

原始出处：

LaurenM.Moore,SunCho,MALDI-TOF mass spectrometry distinguishes daratumumab from M-proteins

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    2019-09-28 lg.zhao

    #M蛋白#

    0

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    2020-03-07 windight

    #CTA#

    0

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    2020-01-11 daviiliu

    #TOF#

    0

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    2019-09-14 snf701207

    #mAb#

    0

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    2020-06-11 docwu2019

    #质谱分析#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1943852, encodeId=e783194385202, content=<a href='/topic/show?id=b6381244635' target=_blank style='color:#2F92EE;'>#M蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12446, encryptionId=b6381244635, topicName=M蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Sat Sep 28 06:31:00 CST 2019, time=2019-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849686, encodeId=72c41849686e5, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Mar 07 18:31:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987485, encodeId=dbe7198e4856c, content=<a href='/topic/show?id=af031e620cf' target=_blank style='color:#2F92EE;'>#TOF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17620, encryptionId=af031e620cf, topicName=TOF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Jan 11 02:31:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912184, encodeId=d5db1912184d6, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sat Sep 14 05:31:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028619, encodeId=601c2028619cc, content=<a href='/topic/show?id=f69c923e62e' target=_blank style='color:#2F92EE;'>#质谱分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92376, encryptionId=f69c923e62e, topicName=质谱分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 11 00:31:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349675, encodeId=b82313496e5d5, content=<a href='/topic/show?id=7b2356991f' target=_blank style='color:#2F92EE;'>#Daratumumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5699, encryptionId=7b2356991f, topicName=Daratumumab)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469411, encodeId=c6f1146941191, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553358, encodeId=e51d1553358cd, content=<a href='/topic/show?id=81bd923e559' target=_blank style='color:#2F92EE;'>#质谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92375, encryptionId=81bd923e559, topicName=质谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96fd14366106, createdName=jeanqiuqiu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
    2019-08-10 yese

    #Daratumumab#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1943852, encodeId=e783194385202, content=<a href='/topic/show?id=b6381244635' target=_blank style='color:#2F92EE;'>#M蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12446, encryptionId=b6381244635, topicName=M蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Sat Sep 28 06:31:00 CST 2019, time=2019-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849686, encodeId=72c41849686e5, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Mar 07 18:31:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987485, encodeId=dbe7198e4856c, content=<a href='/topic/show?id=af031e620cf' target=_blank style='color:#2F92EE;'>#TOF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17620, encryptionId=af031e620cf, topicName=TOF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Jan 11 02:31:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912184, encodeId=d5db1912184d6, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sat Sep 14 05:31:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028619, encodeId=601c2028619cc, content=<a href='/topic/show?id=f69c923e62e' target=_blank style='color:#2F92EE;'>#质谱分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92376, encryptionId=f69c923e62e, topicName=质谱分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 11 00:31:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349675, encodeId=b82313496e5d5, content=<a href='/topic/show?id=7b2356991f' target=_blank style='color:#2F92EE;'>#Daratumumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5699, encryptionId=7b2356991f, topicName=Daratumumab)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469411, encodeId=c6f1146941191, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553358, encodeId=e51d1553358cd, content=<a href='/topic/show?id=81bd923e559' target=_blank style='color:#2F92EE;'>#质谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92375, encryptionId=81bd923e559, topicName=质谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96fd14366106, createdName=jeanqiuqiu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
    2019-08-10 zhangjingnwpu

    #ALD#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1943852, encodeId=e783194385202, content=<a href='/topic/show?id=b6381244635' target=_blank style='color:#2F92EE;'>#M蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12446, encryptionId=b6381244635, topicName=M蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Sat Sep 28 06:31:00 CST 2019, time=2019-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849686, encodeId=72c41849686e5, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Mar 07 18:31:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987485, encodeId=dbe7198e4856c, content=<a href='/topic/show?id=af031e620cf' target=_blank style='color:#2F92EE;'>#TOF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17620, encryptionId=af031e620cf, topicName=TOF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Sat Jan 11 02:31:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912184, encodeId=d5db1912184d6, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sat Sep 14 05:31:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028619, encodeId=601c2028619cc, content=<a href='/topic/show?id=f69c923e62e' target=_blank style='color:#2F92EE;'>#质谱分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92376, encryptionId=f69c923e62e, topicName=质谱分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jun 11 00:31:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349675, encodeId=b82313496e5d5, content=<a href='/topic/show?id=7b2356991f' target=_blank style='color:#2F92EE;'>#Daratumumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5699, encryptionId=7b2356991f, topicName=Daratumumab)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469411, encodeId=c6f1146941191, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553358, encodeId=e51d1553358cd, content=<a href='/topic/show?id=81bd923e559' target=_blank style='color:#2F92EE;'>#质谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92375, encryptionId=81bd923e559, topicName=质谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96fd14366106, createdName=jeanqiuqiu, createdTime=Sat Aug 10 06:31:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
    2019-08-10 jeanqiuqiu

    #质谱#

    0

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