JCEM:2 型糖尿病消瘦患者预后差

2014-10-17 desperado-c 丁香园

由于常常将体重指数(BMI)<18kg/m2 患者排除在外,以往研究中关于 BMI 与糖尿病死亡率之间关系不一定能全面反映整个人群的情况。 为此,来自日本东京大学公共卫生学院 Hirohito Sone 教授及其团队进行了一项研究,调查 2 型糖尿病患者 BMI 与死亡率之间的关系。该研究结

由于常常将体重指数(BMI)<18kg/m2 患者排除在外,以往研究中关于 BMI 与糖尿病死亡率之间关系不一定能全面反映整个人群的情况。

为此,来自日本东京大学公共卫生学院 Hirohito Sone 教授及其团队进行了一项研究,调查 2 糖尿病患者 BMI 与死亡率之间的关系。该研究结果在线发表在 2014 年 09 月 09 日的 The Journal of Clinical Endocrinology & Metabolism 杂志上。

该研究中,Sone 教授等对日本糖尿病并发症研究和日本老年糖尿病干预研究中 2620 例 2 型糖尿病患者 6.3 年随访数据进行汇总分析,排除有心血管疾病或癌症病史的患者。研究重点为全因死亡率。校正年龄、吸烟情况、业余时间体力活动和其他混杂因素后,利用 Cox 回归模型评估不同 BMI 患者全因死亡率的风险比。

Sone 教授等按 BMI 水平将患者分为 4 组:14.4–18.5kg/m2(5.2%)、18.5–22.4kg/m2(37.3%)、22.5–24.9kg/m2(31.0%)和 25.0–37.5kg/m2(26.6%),分析发现,BMI≥18.5kg/m2 患者中死亡率趋势无显著差异。相比之下,与 BMI 22.5–24.9kg/m2 患者相比,BMI<18.5 患者全因死亡率的风险比为 2.58(95%CI 1.38–4.84)。排除随访前 4 年的死亡事件后,此风险比仅略有下降。

该研究提示, BMI 在 18.5~24.9kg/m2 之间的 2 型糖尿病患者死亡率最低,且肥胖对死亡率无明显影响。Sone 教授指出,还需要在消瘦 2 型糖尿病患者中进行进一步的研究,特别是东亚老年人群中。

原文出处

Tanaka S1, Tanaka S, Iimuro S, Akanuma Y, Ohashi Y, Yamada N, Araki A, Ito H, Sone H; for the Japan Diabetes Complications Study Groupthe Japanese Elderly Diabetes Intervention Trial Group.Body mass index and mortality among Japanese patients with type 2 diabetes: Pooled analysis of the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial.J Clin Endocrinol Metab. 2014 Sep 9

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    2015-09-11 achengzhao
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    2015-06-08 ljjj1053

    好好学习学习

    0

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

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    2014-12-03 smallant2015
  6. [GetPortalCommentsPageByObjectIdResponse(id=1691834, encodeId=5f391691834c3, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Fri Mar 27 08:06:00 CST 2015, time=2015-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062865, encodeId=19f22062865cd, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Sep 11 18:06:00 CST 2015, time=2015-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26299, encodeId=212026299e2, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:03:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20526, encodeId=f9d220526e5, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:06:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777484, encodeId=39301e774846b, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Dec 03 18:06:00 CST 2014, time=2014-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742032, encodeId=0e691e420321f, content=<a href='/topic/show?id=6e29658163e' target=_blank style='color:#2F92EE;'>#消瘦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65816, encryptionId=6e29658163e, topicName=消瘦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ab635012667, createdName=fengyqf, createdTime=Wed May 27 09:06:00 CST 2015, time=2015-05-27, status=1, ipAttribution=)]
    2015-05-27 fengyqf

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