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J Dent Res：Msx2标记限制间充质前体细胞群落生长的空间性

2018-05-15 lishiting MedSci原创

Msx2间充质颅面发育
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颅面的发育需要一系列的模式编码，以区域特异性的方式定义迁移后间充质细胞的特征，以局部表达相应的形态发生素，包括成纤维细胞生长因子（FGFs）和骨形态发生蛋白（BMPs），从而提供形态发生引导。Msx2为BMPs信号的靶点，是调控Runx2和osterix (Osx)的转录因子，它的突变会导致人的颅骨畸形。

颅面的发育需要一系列的模式编码，以区域特异性的方式定义迁移后间充质细胞的特征，以局部表达相应的形态发生素，包括成纤维细胞生长因子（FGFs）和骨形态发生蛋白（BMPs），从而提供形态发生引导。Msx2为BMPs信号的靶点，是调控Runx2和osterix (Osx)的转录因子，它的突变会导致人的颅骨畸形。这篇研究显示，Msx2定义了在迁移后阶段的颅面间充质特异性区域存在成骨-成软骨前体细胞，特别是在下颌突及后颅窝区域。对Msx2-creER小鼠的分析显示，早期间充质细胞与基于他莫昔芬注射标记的表达BMP4的间充质相类似，并且他们的后代在晚期对不同类型的间充质细胞起作用，如：软骨细胞和瞬时软骨的软骨膜细胞，以及成骨细胞和骨缝间充质细胞。相反，晚期Osx-creER标记的成骨前体细胞以及它们的后代在出生后阶段可以持续分化为成骨细胞。因此，Msx2标记会在空间上限制间充质前体细胞群落的生长以及多向分化的潜能。结果表明，外部分子信号可以指令发育过程中迁移后间充质细胞的特征发生改变。原始出处：Sakagami N， Matsushita Y， et al. Msx2 Marks Spatiall

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    2018-10-24 heli0118

    #Msx2#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2082041, encodeId=f7f020820418e, content=<a href='/topic/show?id=710e12298c1' target=_blank style='color:#2F92EE;'>#Msx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12298, encryptionId=710e12298c1, topicName=Msx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Oct 24 06:36:00 CST 2018, time=2018-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438320, encodeId=b3841438320c4, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu May 17 11:36:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315417, encodeId=f45531541e78, content=颅面的发育需要一系列的模式编码.以区域特异性的方式定义迁移后间充质细胞的特征.以局部表达相应的形态发生素.包括成纤维细胞生长因子(FGFs)和骨形态发生蛋白(BMPs).从而提供形态发生引导.Msx2为BMPs信号的靶点.是调控Runx2和osterix(Osx)的转录因子.它的突变会导致人的颅骨畸形., beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 15 22:00:16 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315412, encodeId=786631541213, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue May 15 21:41:09 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-17 zhouqu_8

    #体细胞#

    0

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    2018-05-15 有备才能无患

    颅面的发育需要一系列的模式编码.以区域特异性的方式定义迁移后间充质细胞的特征.以局部表达相应的形态发生素.包括成纤维细胞生长因子(FGFs)和骨形态发生蛋白(BMPs).从而提供形态发生引导.Msx2为BMPs信号的靶点.是调控Runx2和osterix(Osx)的转录因子.它的突变会导致人的颅骨畸形.

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2082041, encodeId=f7f020820418e, content=<a href='/topic/show?id=710e12298c1' target=_blank style='color:#2F92EE;'>#Msx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12298, encryptionId=710e12298c1, topicName=Msx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Oct 24 06:36:00 CST 2018, time=2018-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438320, encodeId=b3841438320c4, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu May 17 11:36:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315417, encodeId=f45531541e78, content=颅面的发育需要一系列的模式编码.以区域特异性的方式定义迁移后间充质细胞的特征.以局部表达相应的形态发生素.包括成纤维细胞生长因子(FGFs)和骨形态发生蛋白(BMPs).从而提供形态发生引导.Msx2为BMPs信号的靶点.是调控Runx2和osterix(Osx)的转录因子.它的突变会导致人的颅骨畸形., beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 15 22:00:16 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315412, encodeId=786631541213, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue May 15 21:41:09 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-15 1ddf0692m34(暂无匿称)

    学习了.长知识

    0