Sci Signal：侵略性乳腺癌的新生物标记物

2018-02-05 药明康德学术经纬

很多侵略性乳腺癌 (aggressive breast cancer) 亚型的共同特征是它们携带的基因突变能够模拟生长因子激发细胞增殖和迁移的能力。

很多侵略性乳腺癌 (aggressive breast cancer) 亚型的共同特征是它们携带的基因突变能够模拟生长因子激发细胞增殖和迁移的能力。以色列魏茨曼科学研究所(Weizmann Institute of Science) 的研究人员利用磷酸化蛋白组学 (phosphoproteomic) 技术对接受EGF刺激的乳腺细胞系进行了分析。他们发现一种名为LAD1的蛋白是媒介EGF激活ERK信号通路的重要因子。这种蛋白的活性受到磷酸化的调节。EGFR激活的信号通路能够提高细胞的迁移能力，而LAD1能够调节与细胞迁移相关的肌动蛋白的动态平衡。同时，LAD1在侵略性乳腺癌亚型中高度表达，并且能够预测不良预后。这些发现表明，LAD1可能成为引导临床决策的重要生物标记物。

原始出处：

Lee Roth，et al.SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.Sci Signal.30 Jan 2018：Vol. 11， Issue 515， eaan0949

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#插入话题

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2018-04-21 pps20019

#侵略性#

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2018-10-20 yaanren

#Signal#

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2018-11-10 wjywjy

#标记物#

23 0
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2018-09-18 楚秀娟

#Sign#

29 0
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2018-02-07 12498fa0m11暂无昵称

#生物标记#

25 0
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2018-02-07 hbwxf

#生物标记物#

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Sci Signal：侵略性乳腺癌的新生物标记物

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Sci Signal：侵略性乳腺癌的新生物标记物

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