Lancet:基层医疗骨折风险筛查可有效减低老年女性髋部骨折风险

2017-12-18 zhangfan MedSci原创

研究认为系统的、社区为基础的老年女性骨折风险筛查是可行的,筛查可有效减少髋部骨折风险

尽管有针对骨质疏松症的药物,但积极的骨折风险筛查仍是预防疾病的有效方案。近日研究人员考察了社区筛查干预对老年妇女骨折预防的效果。

研究招募70-85岁的老年女性,利用骨折风险评估工具(FRAX)对其进行评估,正服用处方抗骨质疏松药物和其他不适因素的妇女排除在外。主要终点是在5年内发生1次或多次骨质疏松相关骨折患者比例,次要终点包括至少有1次髋部骨折、任何临床骨折或死亡的比例;以及筛选对参与者焦虑和健康相关生活质量的影响。筛查后,对于髋部骨折高危人群推荐进行药物防治。

12483名女性参与研究,其中6233人随机接受了筛查,898人(14%)推荐接受药物预防。与对照组相比,筛查组在1年内使用骨质疏松药物的比例(15% vs 4%)升高,筛查后高风险患者6个月时的用药比例高达78%。筛查不能降低骨质疏松相关骨折(HR 0.94, 95% CI 0.85-1.03)以及所有临床骨折(0.94, 0.86-1.03)的发生率,但会降低髋部骨折的发生率 (0.72, 0.59-0.89)。筛查不会对患者死亡率、焦虑以及生活质量造成影响。

研究认为系统的、社区为基础的老年女性骨折风险筛查是可行的,筛查可有效减少髋部骨折风险。

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    2018-05-05 howi
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    2018-01-04 jyzxjiangqin

    基层医疗骨折风险筛查.

    0

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    2017-12-23 jyzxjiangqin

    基层医疗骨折风险筛查.

    0

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    2017-12-20 liuquan
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    2017-12-19 jyzxjiangqin

    基层医疗骨折风险筛查.

    0

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    2017-12-18 惠映实验室

    学习了.谢谢.

    0

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