Thorax.:胸部CT上发现的肺囊肿——衰老还是临床意义?

2015-11-08 candy 译 MedSci原创

目的:在一个以人群为基础的队列中探讨肺囊肿的发病率和自然病程,并描述CT图像特征与参与者的人口统计和肺功能的相关性。材料与方法:2633名受试者接受胸部CT扫描(平均年龄为59.2岁;50%是女性),这些受试者来自于Framingham心脏研究(FHS),在视觉上评估肺囊肿的存在和图像特征。这些研究结果与参与者的人口统计、肺功能检查的结果以及CT上独立检测到的肺气肿相关。通过与以前的CT扫描(平均

目的:在一个以人群为基础的队列中探讨肺囊肿的发病率和自然病程,并描述CT图像特征与参与者的人口统计和肺功能的相关性。

材料与方法:2633名受试者接受胸部CT扫描(平均年龄为59.2岁;50%是女性),这些受试者来自于Framingham心脏研究(FHS),在视觉上评估肺囊肿的存在和图像特征。这些研究结果与参与者的人口统计、肺功能检查的结果以及CT上独立检测到的肺气肿相关。通过与以前的CT扫描(平均间隔6.1年)的比较,研究时间间隔的变化。

结果:发现7.6%的受试者有肺囊肿(95% CI 6.6% to 8.7%; 200/2633)。研究者没有发现这其中有40岁以下的受试者。且患病率随年龄增长而增加。多发囊肿(≥5个),在0.9%的所有受试者中发现。肺囊肿的患者表现为明显的低体重指数(BMI) (p<0.001)。肺囊肿是最有可能单独出现在肺下叶的周边区域,随着时间的推移大小始终保持不变或略有增加。肺囊肿对肺功能无显著影响(P = 0.07–0.6),对一氧化碳弥散量(DLCO)有相关性(P = 0.03),和吸烟与肺气肿均无相关性(P = 0.1–0.9;P = 0.7)。

结论:表现在胸部电脑断层扫描上的肺囊肿可能是肺部老化的一部分,发生在年龄40岁以上的无症状个体中,与BMI和DLCO下降有关。而多发性肺囊肿可能需要对囊性肺疾病的可能性进行评估。

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