Neurogastroenterol Motil:维生素D或可改善IBS症状

2016-05-31 Mechront 译 MedSci原创

黏膜低度炎症和免疫激活参与了肠易激综合征(IBS)的发病机制。此外,IBS症状与较高的心理困扰的发生相关,这本身会导致生活质量(QoL)的受损。维生素D通过其对心理因素和炎症的有益影响,进而改善IBS患者的症状。该研究纳入了90名IBS患者,随机分为50 000 IU维生素D和安慰剂对照组,半月服用一次,长达6个月。在基线和每月干预时研究者报告IBS症状相关情况。同时在基线和干预后,患者完成IBS

黏膜低度炎症和免疫激活参与了肠易激综合征(IBS)的发病机制。此外,IBS症状与较高的心理困扰的发生相关,这本身会导致生活质量(QoL)的受损。维生素D通过其对心理因素和炎症的有益影响,进而改善IBS患者的症状。

该研究纳入了90名IBS患者,随机分为50 000 IU维生素D和安慰剂对照组,半月服用一次,长达6个月。在基线和每月干预时研究者报告IBS症状相关情况。同时在基线和干预后,患者完成IBS严重程度评分系统(IBSS)和IBS相关生QoL评分问卷。

结果显示,6个月的维生素D干预让IBS症状如腹痛、腹胀、胀气、轰鸣和胃肠道总体症状(除外排便习惯)均显著改善。维生素D组患者的IBSSS(-53.82±23.3 vs -16.85±25.01,P<0.001)和IBS-QoL评分(14.26±3 vs 11±2.34,P<0.001)有也明显提高。

虽然研究结果支持了维生素D对IBS症状的改善,不过还需要进一步的研究来验证。

原始出处:

Abbasnezhad A,Amani R,et al.Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.Neurogastroenterol Motil 2016 May 7;[Epub ahead of print]

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    2017-04-10 许安
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Jun 01 16:15:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88051, encodeId=2c8288051b7, content=这个不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Wed Jun 01 15:36:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87976, encodeId=62fe8e97632, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-02 yulin2006
  5. 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createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 小马飞刀

    学习了,感谢

    0

  6. 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createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 醉清风

    学习了,值得阅读!

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Jun 01 16:15:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88051, encodeId=2c8288051b7, content=这个不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Wed Jun 01 15:36:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87976, encodeId=62fe8e97632, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 沉心多思

    这个不错的

    0

  8. 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encryptionId=04ab931993, topicName=IBS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Thu Jun 02 13:34:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88112, encodeId=203b88112e9, content=学习了,感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160922/IMG57E3868CA52422858.jpg, createdBy=da5d1716996, createdName=小马飞刀, createdTime=Wed Jun 01 22:51:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88090, encodeId=46b7880905e, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Jun 01 16:15:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88051, encodeId=2c8288051b7, content=这个不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Wed Jun 01 15:36:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87976, encodeId=62fe8e97632, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 1dd8c52fm63(暂无匿称)

    学习学习!

    0

  9. 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encryptionId=04ab931993, topicName=IBS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Thu Jun 02 13:34:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88112, encodeId=203b88112e9, content=学习了,感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160922/IMG57E3868CA52422858.jpg, createdBy=da5d1716996, createdName=小马飞刀, createdTime=Wed Jun 01 22:51:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88090, encodeId=46b7880905e, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Jun 01 16:15:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88051, encodeId=2c8288051b7, content=这个不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Wed Jun 01 15:36:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87976, encodeId=62fe8e97632, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 龙胆草

    学习了,很期待。

    0

  10. 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createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 01 07:32:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87975, encodeId=f4088e97570, content=学习了,很期待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jun 01 07:28:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87974, encodeId=ce6a8e9742c, content=学习了,值得阅读!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Wed Jun 01 07:24:00 CST 2016, time=2016-06-01, status=1, ipAttribution=)]
    2016-06-01 lietome1

    学习了,值得阅读!

    0

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