J Neuroophthalmol:特发性颅内高压患者的腰椎穿刺后续持续性低压综合征的发生率和危险因素

2018-09-27 MedSci MedSci原创

华盛顿大学医学院眼科学与视觉科学系的Lu P近日在J Neuroophthalmol杂志上发表了一项重要的研究,探讨特发性颅内高压(IIH)患者腰椎穿刺(LP)后持续性低压综合征的发生率和潜在危险因素.

华盛顿大学医学院眼科学与视觉科学系的Lu P近日在J Neuroophthalmol杂志上发表了一项重要的研究,探讨特发性颅内高压(IIH)患者腰椎穿刺(LP)后持续性低压综合征的发生率和潜在危险因素。

他们通过临床检查和LP对明确诊断为IIH的患者进行了回顾性图表分析,并将其与多发性硬化症(MS)患者进行比较,其中多发性硬化症(MS)患者也接受了LPs。收集每位患者的人口统计学、临床和放射学的数据。主要结果指标是IIH患者与MS患者相比,LP后需要进行输血的发生率。次要结果测量是与年龄、体重指数、穿刺移除体积、开放压力、开放和闭合压力之间的差异,以及IIH群组内的穿刺水平相关的硬膜外输血。

研究中包括114名IIH患者和149名MS患者。在IIH患者中,12/104(11.5%)在LP后出现硬膜外输血的病例,而MS对照组患者为8/149(5.4%)(P = 0.086)。在IIH人群中,临床或LP参数都没有与输血风险增加呈现出显着相关的特征。

因此,他们认为,通过输血测量的低压综合征的发生率在IIH患者和MS对照中是相似的。这表明在LP之前颅内压升高,并不能防止发生针刺后出现的低压综合征,这与常见的假设不一样。

原文出处:

Lu, P., et al., Identifying Incidence of and Risk Factors for Fluoroscopy-Guided Lumbar Puncture and Subsequent Persistent Low-Pressure Syndrome in Patients With Idiopathic Intracranial Hypertension. J Neuroophthalmol, 2018.

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  5. 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  6. 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  7. 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objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100434, encryptionId=868710043450, topicName=颅内高压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e4326942691, createdName=mgqwxj, createdTime=Thu Oct 25 19:35:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894697, encodeId=371f189469ebd, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sun Feb 24 08:35:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805842, encodeId=74d8180584245, content=<a href='/topic/show?id=a101e900524' target=_blank style='color:#2F92EE;'>#续持续性低压综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79005, encryptionId=a101e900524, topicName=续持续性低压综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Wed Oct 03 18:35:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272091, encodeId=9b7b12e209192, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311919, encodeId=5c3813119197a, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431335, encodeId=cf1914313359a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541393, encodeId=de01154139387, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=)]
  8. 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objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100434, encryptionId=868710043450, topicName=颅内高压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e4326942691, createdName=mgqwxj, createdTime=Thu Oct 25 19:35:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894697, encodeId=371f189469ebd, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sun Feb 24 08:35:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805842, encodeId=74d8180584245, content=<a href='/topic/show?id=a101e900524' target=_blank style='color:#2F92EE;'>#续持续性低压综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79005, encryptionId=a101e900524, topicName=续持续性低压综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Wed Oct 03 18:35:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272091, encodeId=9b7b12e209192, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311919, encodeId=5c3813119197a, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431335, encodeId=cf1914313359a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541393, encodeId=de01154139387, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=)]
    2018-09-29 rgjl
  9. 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  10. 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