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Stroke：CADASIL患者的局部宏观皮质病变

2017-03-28 xing.T MedSci原创

CADASIL局部宏观皮质病变
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由此可见，在CADASIL患者发展到最后阶段之前很长一段时间内，局部宏观皮质病变可以通过使用特定的磁共振成像方法来进行检测。这些皮质变化的潜在机制和精确的临床结局仍然需要进一步研究来确定。

皮质微梗死和继发性皮层退行性病变已被证明存在于常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病（CADASIL）中，CADASIL是一种严重的缺血性脑小血管疾病。近日，卒中领域权威杂志Stroke上发表了一篇研究文章，该研究旨在明确使用特定的体内磁共振成像方法是否可以检测出局部宏观皮质病变。

研究人员纳入了28例非痴呆非残疾的CADASIL患者以及29例年龄和性别相匹配的对照者，并且获得这些参与者的三维T1磁共振成像扫描结果。患者和对照者的皮层由一名有经验的BrainVisa用户进行提取，并且专门的阅读图片期间由第二名不知道参与者临床状态的研究者在去除白质后进行评估。此后，使用所有可用的成像数据来归纳确定的局部宏观皮质病变的特点，包括某些患者的7-T磁共振成像。

研究人员发现在28例CADASIL患者中有3例患者（11%）被确认存在局部宏观皮质病变，而29例对照者中无1例存在这样的病变。所有病变均是在潜在白质的严重信号改变的附近被观察到的。

由此可见，在CADASIL患者发展到最后阶段之前很长一段时间内，局部宏观皮质病变可以通过使用特定的磁共振成像方法来进行检测。这些皮质变化的潜在机制和精确的临床结局仍然需要进一步研究来确定。

原始出处：

Aicha Lyoubi-Idrissi,et al. Focal Macroscopic Cortical Lesions in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.116.015724

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    2017-06-15 sunmin0231

    #CADASIL#

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    2018-02-22 12498dd9m11暂无昵称

    #皮质病变#

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    2017-04-04 0643

    赞

    0

  4. 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topicName=ADA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Mar 30 10:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405714, encodeId=14131405e14bb, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Thu Mar 30 10:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183488, encodeId=c4861834888e, content=长知识，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), 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    2017-03-30 般若傻瓜

    #ADA#

    0

  5. 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), 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    2017-03-30 chg122

    #局部#

    0

  6. 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    2017-03-29 jacob9231

    长知识，谢谢

    0

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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183317, encodeId=b9c418331ea0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEudJO7WUea4BZ0iamO76bia2tTguja1n4ZQ57rr6RIkMqaTOn102bgBTjFlh26J7cH0hsLBoxyVcB/0, createdBy=b91b1726746, createdName=ideal肿瘤医, createdTime=Tue Mar 28 20:05:27 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-29 shaosai

    好好学习，涨知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1752029, encodeId=0c3a1e5202967, content=<a href='/topic/show?id=15ba396ece' target=_blank style='color:#2F92EE;'>#CADASIL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3967, encryptionId=15ba396ece, topicName=CADASIL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e99536423166, createdName=sunmin0231, createdTime=Thu Jun 15 15:38:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800250, encodeId=932c180025095, content=<a href='/topic/show?id=01c0e2168fc' target=_blank style='color:#2F92EE;'>#皮质病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72168, encryptionId=01c0e2168fc, topicName=皮质病变)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183317, encodeId=b9c418331ea0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEudJO7WUea4BZ0iamO76bia2tTguja1n4ZQ57rr6RIkMqaTOn102bgBTjFlh26J7cH0hsLBoxyVcB/0, createdBy=b91b1726746, createdName=ideal肿瘤医, createdTime=Tue Mar 28 20:05:27 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-29 tanxingdoctor

    不错的文章，谢谢分享

    0

  9. 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183317, encodeId=b9c418331ea0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEudJO7WUea4BZ0iamO76bia2tTguja1n4ZQ57rr6RIkMqaTOn102bgBTjFlh26J7cH0hsLBoxyVcB/0, createdBy=b91b1726746, createdName=ideal肿瘤医, createdTime=Tue Mar 28 20:05:27 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 三指郎

    学习了

    0

  10. 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Mar 29 00:08:02 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183337, encodeId=9c4218333e5e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcywjFtfnWDO3RgXLrTNK0usM5YiaeRKQ2JC8iahM4VajU0WoXJBepYUJCveYL4By4CeoHbOmCWcjYHfkAdQaW149/0, createdBy=d91a2022197, createdName=三指郎, createdTime=Tue Mar 28 22:01:29 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183317, encodeId=b9c418331ea0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEudJO7WUea4BZ0iamO76bia2tTguja1n4ZQ57rr6RIkMqaTOn102bgBTjFlh26J7cH0hsLBoxyVcB/0, createdBy=b91b1726746, createdName=ideal肿瘤医, createdTime=Tue Mar 28 20:05:27 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 ideal肿瘤医

    学习了

    0

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研究结果表明急性低血压的血管反应性受损可以加速CADASIL病理进展。此外，受影响白质区域的静脉胶原病在维护白质完整性上发挥了重要作用，虽然在很大程度上被忽视。

Stroke：CADASIL患者软脑膜动脉存在显著的内膜增生但管腔不狭窄

CADASIL软脑膜动脉存在显著的内膜增生但没有管腔狭窄 软脑膜动脉异常还没有专门列为CADASIL（伴皮层下梗死和脑白质病变的常染色体显性遗传性脑动脉病）的一个特征。为此，美国密歇根大学神经科的Hairong Dong博士等人进行了一项研究，研究结果在线发表在2013年3月12日的Stroke杂志上。研究结果显示：CADASIL软脑膜动脉的主要改变包括内膜增厚和中膜变薄，但不包括管腔变窄。