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J Clin Periodontol：辅助使用褪黑素可有效治疗肥胖相关的牙周炎

2018-09-23 MedSci MedSci原创

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本研究旨在探究辅助全身给予褪黑素对实验性牙周炎肥胖大鼠常规机械牙周治疗的影响。 在初始体重为180g的42只Wistar大鼠中，一半（n = 21）用高脂肪饮食喂养以诱导肥胖。在肥胖组和正常体重组中，随后通过牙龈卟啉单胞菌和具核梭杆菌口服强饲诱导实验性牙周炎。两组随机分配到常规机械治疗或牙周治疗，辅助使用氯己定或褪黑激素。结果通过临床参数（探测深度改良牙龈指数，斑斑指数和探诊出血），骨吸收和

本研究旨在探究辅助全身给予褪黑素对实验性牙周炎肥胖大鼠常规机械牙周治疗的影响。

在初始体重为180g的42只Wistar大鼠中，一半（n = 21）用高脂肪饮食喂养以诱导肥胖。在肥胖组和正常体重组中，随后通过牙龈卟啉单胞菌和具核梭杆菌口服强饲诱导实验性牙周炎。两组随机分配到常规机械治疗或牙周治疗，辅助使用氯己定或褪黑激素。结果通过临床参数（探测深度改良牙龈指数，斑斑指数和探诊出血），骨吸收和血浆和牙龈组织中的生物标志物水平（炎性细胞因子，胰岛素，瘦素，骨钙素，骨桥蛋白，纤溶酶原激活物抑制剂-1，细胞间粘附分子1，E-选择素和脂质）进行评估。

结果显示，与同组辅助使用CHX或正常体重辅助使用褪黑激素或CHX的大鼠相比，肥胖-牙周炎组辅助褪黑素给药导致牙龈炎症和探诊出血减少，正如Micro-CT检查显示探诊深度显著减少和骨修复增强（牙槽骨破坏减少15％）所示。与其他组相比，褪黑激素治疗的肥胖-牙周炎组中，在牙龈和血浆样品中也显示出对化学生物标记物的明显影响，其中促炎细胞因子的水平显著降低。

综上所述，该研究结果表明，辅助使用褪黑激素治疗可显著减少牙槽骨损失，并且主要在受牙周炎和肥胖症共病影响的那些实验动物中发挥保护性抗炎作用。

原始出处：

Virto L, Cano P, et al., Melatonin as adjunctive therapy in the treatment of periodontitis associated with obesity. J Clin Periodontol. 2018 Sep 21. doi: 10.1111/jcpe.13013.

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    2019-03-21 feather89

    #PE#

    0

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    2018-09-24 医者仁心

    #牙周#

    0

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    2018-09-24 docwu2019

    #有效治疗#

    0

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    2018-09-23 医者仁心5538

    学习了

    0

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    2018-09-23 明月清辉

    谢谢分享，学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1727603, encodeId=5be21e2760370, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Mar 21 02:20:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451011, encodeId=c1d814510113d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Sep 24 16:20:00 CST 2018, time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619522, encodeId=021416195222a, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Sep 24 16:20:00 CST 2018, time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346283, encodeId=ea86346283f6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Sep 23 09:40:28 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346260, encodeId=30683462605e, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Sep 23 08:26:13 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346248, encodeId=55b73462488b, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 23 07:23:42 CST 2018, time=2018-09-23, status=1, ipAttribution=)]
    2018-09-23 liumin1987

    嗯嗯，学习了。

    0