Sci Rep:血小板/淋巴细胞比例在泌尿肿瘤中的预后意义

2017-12-03 AlexYang MedSci原创

在之前的研究中,血小板与淋巴细胞比例(PLR)和泌尿肿瘤生存之间的关系的研究结果并不一致。因此,最近,有研究人员进行了元分析来评估患有泌尿肿瘤的病人中PLR的预后意义。研究人员在PubMed、Embase和Web of Science数据库中进行了文献搜索,搜索的文献的时间到2017年7月,研究质量利用 Newcastle-Ottawa Scale评分系统进行分析。为了评估PLR和总生存(OS)和

在之前的研究中,血小板与淋巴细胞比例(PLR)和泌尿肿瘤生存之间的关系的研究结果并不一致。因此,最近,有研究人员进行了元分析来评估患有泌尿肿瘤的病人中PLR的预后意义。

研究人员在PubMed、Embase和Web of Science数据库中进行了文献搜索,搜索的文献的时间到2017年7月,研究质量利用 Newcastle-Ottawa Scale评分系统进行分析。为了评估PLR和总生存(OS)和其他生存结果在泌尿肿瘤中的关系,研究人员利用了合并风险比例分析(HRs),并且在不同的种族、样本大小和截断值中进行了亚群分析。

研究总共包括了20个高质量的研究,参与的病人数达7562名,这些病人均患有泌尿肿瘤。研究发现,高预处理PLR与患有泌尿癌症病人的OS显著相关(合并HR=1.58)。提高的PLR与其他生存结果同样存在相关性。然而,研究人员发现,PLR与患有不同类型泌尿癌症(除了膀胱癌)(BCa, HR=1.16, 95%CI: 0.96-1.41)病人的OS具有显著的相关性。最后,研究人员指出,提高的PLR与患有泌尿癌症病人的OS呈现负相关关系。然而,在未来的研究中仍旧需要更大规模的和高质量的前瞻性研究。

原始出处:

Dong-Yang Li, Xuan-Yu Hao, Tian-Ming Ma et al. The Prognostic Value of Platelet-to-Lymphocyte Ratio in Urological Cancers: A Meta-Analysis. Sci Rep. 13 Nov 2017.

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