JAMA Ophthalmol:青光眼眼内压测量方法比较

2017-05-15 zhangfan MedSci原创

相比于PASCAL动态轮廓眼压计测试法,Goldmann压平眼压计对于薄角膜和晚期青光眼检测准确性低,采用Goldmann压平眼压计产生不可预知测量误差风险增加

眼内压(IOP)测量的准确测定对于青光眼的诊断和治疗至关重要,但目前缺乏对于Goldmann压平眼压计(GAT)的客观临床评价。近日研究人员就传统GAT与 PASCAL动态轮廓眼压计(DCT)对眼内压测量结果的差异进行了比较。

研究在2011年至2016年进行,112例青光眼患者参与,对患者随机进行GAT 和 DCT法眼内压测量。研究的主要终点是GAT 和 DCT测量校正或未校正的一致度,次要终点是通过青光眼严重程度评分确定的不一致眼压测量与青光眼分期的关系。

参与研究的112名患者,其中女性57人,男性45人,平均年龄66.3岁,其中左眼患者63人(56.3%),85人(75.9%)服用抗高血压药物。DCT测量的平均IOP为20.3mm Hg(95% CI,19.4-21.1),GAT测量的平均IOP为17.0 mm Hg (95% CI,16.3-17.8)。DCT与GAT平均差异为-3.3 mm Hg (95% CI,2.9-3.6)。相比于DCT,5项修正公式修正后的GAT值范围从-2.7至-5.4 mm Hg。平均德累斯顿公式校正的结果为17.6 mm Hg,与DCT测量结果更接近。平均青光眼严重度评分为4.7分(95% CI, 4.1-5.4)。裸眼不一致DCT内压-GAT内压与青光眼严重度评分呈正相关(rs=0.33; P<0.001),与角膜中央厚度呈负相关(rs=-0.22; P=0.02)

研究认为,相比于PASCAL动态轮廓眼压计测试法,Goldmann压平眼压计对于薄角膜和晚期青光眼检测准确性低,采用Goldmann压平眼压计产生不可预知测量误差风险增加。

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    2017-05-15 dhzzm

    学习了分享了

    0

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    2017-05-15 qjzhai1623

    学习

    0

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    2017-05-15 1e1a50a1m36(暂无匿称)

    眼内压测量的准确测定对于青光眼的诊断和治疗至关重要,

    0

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根据世界卫生组织2005年公布的数字,青光眼是全球第二位致盲因素,仅次于白内障。全球共有7000万青光眼患者,估计2020年将达到8000万。因青光眼引起双眼失明者占全球盲人总数的50%。眼科专家提醒,青光眼具有隐匿性与较大的危害性,近年来年轻人患青光眼的人数也是越来越多,青光眼已不再是老年人的“专利”。在世界青光眼日之际,小编汇总盘点了与青光眼相关的研究进展,与大家分享。【1】Science

PNAS:眼压升高是造成青光眼早期过免疫反应的直接原因

这项研究证明,高眼压是造成青光眼早期过免疫反应的直接原因,过免疫反应从而造成眼神经损伤和视网膜神经节细胞的损伤,而补体C3和EGFR信号的抑制这一损伤的造成。

Curr Opin Ophthalmol:青光眼治疗药物新分类

在1996年,美国批准拉坦前列腺素(进口)作为一类新的化学药物(前列腺素类似物),用于高压眼和青光眼的局部治疗。在后来的20多年,全球范围内一直没有新类型的降眼压药物获得批准,几乎都是在原来的降眼压药物基础上,更改剂量剂型或者对药物配方进行改进。

JAMA Ophthalmol:反复玻璃体内贝伐单抗注射与青光眼手术风险的关联

玻璃体腔内注射抗血管生长因子(VEGF)药物与持续升高的眼内压有关,而持续升高的眼内压可能会导增加青光眼手术可能性,以手术方法降低眼内压。

精华指南专题:青光眼诊疗更优方案,国际青光眼日看指南答疑解惑

         青光眼是全世界第二位致盲性眼病,该疾病具有隐匿性,相当一部分患者在患病初期并不知道自己已经患有青光眼,有调查显示,发展国家中约有90%以上的青光眼患者对自己的疾病知之甚少。为了提高青光眼的知晓率,世界青光眼联合会(World Glaucoma Association ,WGA)和世界青光眼患者联合会(World Glaucoma