JACC:心功能不全的患者也可进行肾移植

2015-10-13 崔倩 译 MedSci原创

心功能不全影响肾移植候选人的选择。目前有关于肾移植后心肌恢复和长期结果的预测数据的较缺乏。本研究的目的是确定肾脏移植人群反向重构的程度的和这些变化的预测银子,并评估在这些患者中的结果。研究人员回顾了克利夫兰诊所2003至13年232例谁接受肾移植患者的基线和移植后超声心动图数据;患者同时进行心脏移植的被排除在外。LV左室功能障碍的患者移植后平均左室射血分数(LVEF)有所改善(从41%提高到50%

既往认为心功能不全会影响肾移植候选人的选择。目前有关于肾移植后心肌恢复和长期结果的预测的数据较缺乏。本研究的目的是确定肾脏移植人群反向重构的程度的和这些变化的预测因子,并评估这些预测因子造成的结果。

研究人员回顾了克利夫兰诊所2003至2013年间的232例接受肾移植的患者的基线和移植后超声心动图数据;同时进行心脏移植的患者被排除在外。

左室功能障碍的患者移植后平均左室射血分数(LVEF)有所改善(从41%提高到50%,P <0.0001;n=66)。有一些其他参数得到显著改善,包括舒张功能、LV舒张末期内径、LV重量和右心室收缩压。在调整了多种临床变量后,移植后增加的血红蛋白改善了LVEF(比值比:1.50;95%可信区间(Cl):1.07〜2.14;P=0.016),降低了死亡率(风险比[HR]:0.65;95%Cl:0.49〜0.87;p= 0.004)。LVEF≥10%的改善可独立预测移植前LVEF的生存情况(HR:0.46;95%Cl:0.21〜0.93;P=0.031)。

肾移植可改善心脏结构和功能,赋予了生存的优势;同时,在移植后的血红蛋白的升高是这种变化的显著因子。

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    2016-06-25 hbwxf
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    2015-10-14 这片天

    肾移植后 要改变那么整体上应该还有改变 不仅仅只是在新功能上 希望有其他方面的研究

    0

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