Neurosurgery:退行性脊髓型颈椎病患者术后功能恢复与脑神经结构连接恢复有关

2022-03-06 影像小生 MedSci原创

皮质脊髓束和其它感觉运动通路的微结构完整性的恢复,以及感觉和运动相关区域内微结构连接的脊髓上重组与手术减压后的神经功能改善有关。

退行性脊髓型颈椎病 (DCM) 的特征是导致颈椎管狭窄的慢性骨关节炎变化,其可导致进行性神经功能障碍和身体残疾。感觉和运动皮层的代偿性重组已被证明在限制 DCM 患者的神经功能恶化中起着重要作用。神经可塑性使得通过修改预先存在的连接或创建新的回路来恢复结构和功能连接网络成为可能。

退行性脊髓型颈椎病 (DCM) 患者手术后沿感觉运动束轴突传导的进行性丧失是否可以恢复,以及随后的适应性显微结构变化是否与神经功能改善有关仍然未知。

加利福尼亚大学Langston T. Holly等在Neurosurgery杂志发表题为Recovery of Supraspinal Microstructural Integrity and Connectivity in Patients Undergoing Surgery for Degenerative Cervical Myelopathy的研究文章,研究了DCM 患者手术减压后微结构完整性的上游恢复和微结构连接的重组情况。

该研究收集了22例DCM患者(年龄=56.9±9.1岁)的术前和术后脑弥散张量成像和弥散谱成像数据。采用配对 t 检验识别队列内显著的微观结构变化,并使用相关性分析来确定这些变化是否与神经系统改善相关。

术前,在前额叶/额叶、前扣带回、内外囊以及放射冠纤维的前部、后部和上部区域观察到更高的结构连接性(SC)。

手术后,改良的日本骨科协会评分增加与从初级感觉运动区到后扣带回和楔前叶的 SC 增加有关;小脑和双侧舌回之间的 SC 增加;从边缘系统区域到基底神经节和额叶的 SC 减少。

术前术后患者标准化各向异性值存在差异的脑区

此外,负责传递感觉信息和运动协调和计划的白质纤维FA和标准化的定量各向异性值增加与手术后 DCM 患者的神经系统改善有关。

DCM患者术后FA值增加与mJOA评分增加的相关性(ΔmJOA)

mJOA得分与四个纤维束FA值相关性

总之,该团队认为皮质脊髓束和其它感觉运动通路的微结构完整性的恢复,以及感觉和运动相关区域内微结构连接的脊髓上重组与手术减压后的神经功能改善有关

原文出处

Wang C, Ellingson BM, Salamon N, Holly LT. Recovery of Supraspinal Microstructural Integrity and Connectivity in Patients Undergoing Surgery for Degenerative Cervical Myelopathy [published online ahead of print, 2022 Jan 27]. Neurosurgery. 2022;10.1227/NEU.0000000000001839. doi:10.1227/NEU.0000000000001839

https://journals.lww.com/neurosurgery/Abstract/9900/Recovery_of_Supraspinal_Microstructural_Integrity.106.aspx

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    2022-12-15 siiner
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    2023-01-02 chg121
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    2022-03-06 ms6000000755974223

    神经相当于中医的经络吗?

    0

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    2022-03-03 lsndxfj
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  7. [GetPortalCommentsPageByObjectIdResponse(id=2021727, encodeId=48522021e27c5, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Fri Dec 02 06:07:40 CST 2022, time=2022-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709631, encodeId=07741e096319b, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Thu Dec 15 10:07:40 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877767, encodeId=6efe18e776798, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Mon Jan 02 08:07:40 CST 2023, time=2023-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1199936, encodeId=0df1119993625, content=神经相当于中医的经络吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34446512602, createdName=ms6000000755974223, createdTime=Sun Mar 06 16:58:47 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364785, encodeId=0b281364e8550, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Mar 03 11:07:40 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575691, encodeId=4e6815e569159, content=<a href='/topic/show?id=f5598459992' target=_blank style='color:#2F92EE;'>#脊髓型颈椎病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84599, encryptionId=f5598459992, topicName=脊髓型颈椎病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e89e16147789, createdName=w984450tii, createdTime=Thu Mar 03 11:07:40 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599355, encodeId=07ec1599355bd, content=<a href='/topic/show?id=5eb4329159a' target=_blank style='color:#2F92EE;'>#功能恢复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32915, encryptionId=5eb4329159a, topicName=功能恢复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e9518693674, createdName=mnda, createdTime=Thu Mar 03 11:07:40 CST 2022, time=2022-03-03, status=1, ipAttribution=)]
    2022-03-03 mnda