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CLIN CANCER RES：肿瘤切除可以募集效应T细胞并增强胶质瘤干细胞疗效

2017-11-28 MedSci MedSci原创

胶质瘤肿瘤切除免疫治疗
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尽管肿瘤切除是胶质瘤一线的临床治疗方式，但是有很多临床前免疫治疗模型进行胶质瘤治疗的研究。减瘤手术诱导的免疫反应联合免疫因子输入为胶质瘤免疫治疗提供了一种新的治疗模式。CLIN CANCER RES近期发表了一篇文章研究这一问题。

尽管肿瘤切除是胶质瘤一线的临床治疗方式，但是有很多临床前免疫治疗模型进行胶质瘤治疗的研究。减瘤手术诱导的免疫反应联合免疫因子输入为胶质瘤免疫治疗提供了一种新的治疗模式。CLIN CANCER RES近期发表了一篇文章研究这一问题。作者建立了肿瘤切除原位胶质瘤鼠模型，研究肿瘤切除的免疫反应。作者还建立了大量分泌免疫因子IFNβ的工程化鼠间充质干细胞（MSC-IFNβ）并评估颅内胶质瘤肿瘤切除是否可以显着增强MSC-IFNβ的抗肿瘤活性。研究结果表明，减瘤后髓系抑制性细胞（MDSC）持续减少并刺激CD4/CD8T细胞募集。这一免疫反应可以通过增强术后CD8T细胞浸润以及直接诱导肿瘤细胞细胞周期阻滞显着增强MSC-IFNβ的抗肿瘤活性，最终延长鼠的生存。利用人胶质瘤肿瘤异种移植原位切除模型，作者发现IFNβ可以诱导细胞周期阻滞使细胞凋亡，从而延长免疫缺陷鼠的生存时间，尽管这些老鼠缺乏完整的免疫系统。文章最后认为，该研究证明了原位肿瘤切除模型在肿瘤免疫治疗发展中的重要作用，局部输入免疫治疗性药物治疗肿瘤具有转化潜力。原始出处：Sung Hugh Choi,Daniel W.Stuckey,et

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    2018-06-22 bshuang

    #胶质瘤干细胞#

    0

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    2018-03-21 12498561m41(暂无昵称)

    #肿瘤切除#

    0

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    2017-12-11 虈亣靌

    值得进一步研究

    0

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    2017-11-29 虈亣靌

    不错的.学习了!谢谢分享!

    0

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    2017-11-28 衣带渐宽

    学习

    0

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约40%的胶质瘤有EGFR基因扩增，其中接近一半的肿瘤表达EGFRvⅢ。EGFRvⅢ在EGFR扩增胶质瘤患者中的预后意义以及原发和复发胶质瘤EGFRvⅢ表达改变尚存在争议，但是这些数据对EGFRvⅢ靶向治疗很有意义。CLIN CANCER RES近期发表了一篇文章， 对其进行了研究。

Front Mol Neurosci：HOTAIR或为胶质瘤的治疗提供新的靶标

研究已证实长链非编码RNA（lncRNA）的Homeobox转录反义中间体RNA（HOTAIR）在各种肿瘤的生物学特性中发挥着关键的作用。本研究旨在探究HOTAIR在体外调节血液肿瘤屏障（BTB）渗透性的作用和可能的分子机制。本课题组既往研究发现神经胶质瘤微血管内皮细胞（GECs）中HOTAIR和上游刺激因子1（USF1）的表达上调，而miR-148b-3p的表达下调。敲除HOTAIR可增加BTB