Clinica Chimica Acta:心脏生物标记物而非血管粥样硬化指标可预测外周动脉疾病患者的死亡率

2019-09-21 gladiator MedSci原创

研究发现,外周动脉疾病(PAD)随着年龄的增长而变得更加普遍,并与心血管事件的风险升高和预期寿命缩短有关。在此,本研究研究了一组PAD患者的心脏和血管生物标志物的预后表现。

研究发现,外周动脉疾病(PAD)随着年龄的增长而变得更加普遍,并与心血管事件的风险升高和预期寿命缩短有关。在此,本研究研究了一组PAD患者的心脏和血管生物标志物的预后表现。

总共有95外周动脉疾病患者登记(平均年龄68 ,47-86范围 ,73男性)。测量颈动脉内膜-中膜厚度(cIMT)、踝肱指数(ABI)、高敏感心肌肌钙蛋白Tn -末端b型利钠肽(NT-proBNP)

研究显示,在9.5年的中位随访时间,44例死亡,51例存活。在Kaplan-Meier生存分析HS-肌钙蛋白(P <0.001)或NT-proBNP水平(P <0.001)高于中位数,而CIMT不高于中位数(P = 0.488)或ABI低于中位数(P <.436)与降低的存活率相关联。在单变量Cox回归和校正年龄,性别,以前脑动脉疾病和糖尿病后,仅HS-cTnT和死亡率之间的关联仍然显著(HR 1.93; 95CI 1.33-2.79P <0.001)。操作者曲线分析HS-肌钙蛋白(曲线[AUC]下的面积:0.7795CI0.67-0.87P <0.001)的NT-proBNPAUC0.7495CI0.64-0.84P < 0.001)以及HS-肌钙蛋白,和NT-proBNP组合(AUC0.7995CI0.69-0.88P <0.001)明显优于CIMTAUC0.6495%,CI0.53-0.76 P = 0.022)和ABIAUC0.5795CI0.44-0.68P = 0.313)中的死亡率鉴别风险。

研究表明,PAD患者的预后应考虑hs-cTnTNT-proBNP

原始出处:

Robert K. ClemensWijtske AnnemaCardiac biomarkers but not measures of vascular atherosclerosis predict mortality in patients with peripheral artery disease

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    2020-05-28 wjywjy
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    2020-06-07 windight
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