J Appl Oral Sci:光生物调节疗法可促进临界尺寸骨缺损的骨修复

2018-06-24 MedSci MedSci原创

骨缺损的修复引起了多个专业研究人员的兴趣。已经研究探究了使用骨替代物和激光疗法的移植技术来代替自体骨并加速骨愈合过程。本研究旨在评估光生物调节疗法(PBMT)与引导骨再生(GBR)治疗临界尺寸缺损的效果。研究纳入了80只Wistar雄性大鼠,通过手术在其颅盖上制备临界尺寸缺损,然后分成8个研究组:C组(对照-仅血凝块);M组(胶原膜);PBMT组(光生物调节疗法);AB组(自体骨);AB + PB

骨缺损的修复引起了多个专业研究人员的兴趣。已经研究探究了使用骨替代物和激光疗法的移植技术来代替自体骨并加速骨愈合过程。本研究旨在评估光生物调节疗法(PBMT)与引导骨再生(GBR)治疗临界尺寸缺损的效果。

研究纳入了80只Wistar雄性大鼠,通过手术在其颅盖上制备临界尺寸缺损,然后分成8个研究组:C组(对照-仅血凝块);M组(胶原膜);PBMT组(光生物调节疗法);AB组(自体骨);AB + PBMT组;AB + M组;PBMT + M组;AB + PBMT + M组。术后30天处死动物。组织处理后,通过组织形态计量分析评估骨再生并进行统计学分析(Tukey检验,p <0.05)。

结果显示,与C组相比,其他各组新骨形成面积均增加(9.96±4.49%)。PBMT + M组新骨量最多(达到64.09±7.62%),其次为PBMT组(47.67±8.66%),M组(47.43±15.73%),AB + PBMT组(39.15±16.72%),AB + PBMT + M组(35.82±7.68%)。除了C组,AB(25.10±16.59%)和AB + M组新生骨量最少(22.72±13.83%)。AB + M组(14.93±8.92%)和AB + PBMT + M组(14.76±6.58%)的残留颗粒面积无统计学差异。

综上所化,该研究结果表明,与骨再生技术相关的PBMT利用可能对骨修复有效。

原始出处:

Freitas NR, Guerrini LB, et al., Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study. J Appl Oral Sci. 2018;26:e20170244. doi: 10.1590/1678-7757-2017-0244. Epub 2018 May 7.

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    2019-03-15 小几洁
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    2019-03-14 axin020
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    2018-06-26 lfcmxl
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    2018-06-25 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-06-24 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2020438, encodeId=f143202043859, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Mar 15 18:48:00 CST 2019, time=2019-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719489, encodeId=803f1e19489e4, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Thu Mar 14 16:48:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419265, encodeId=6fca141926513, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Tue Jun 26 12:48:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326749, encodeId=ba00326e49b9, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jun 25 00:07:27 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326726, encodeId=26ca326e268e, content=不错的文章值得拥有哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jun 24 23:36:48 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326719, encodeId=d182326e191d, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Jun 24 23:31:04 CST 2018, time=2018-06-24, status=1, ipAttribution=)]
    2018-06-24 惠映实验室

    学习了.谢谢分享.

    0