Diabetologia:1型糖尿病增加癫痫发病风险

2016-04-07 徐媛 MedSci原创

1型糖尿病显然已成为全球性的重大公共卫生问题,1型糖尿病可能会伴随潜在的神经并发症。有研究表明1型糖尿病与癫痫之间存在相关性,但并没有进行更多的相关研究,本研究旨在评估在中国台湾1型糖尿病和癫痫之间的关系。研究人员收纳了来自台湾全民健康保险研究数据库(NHIRD)2568名1型糖尿病患者的数据,并进行了回顾性队列分析。与对照组相比,在1型糖尿病患者中患癫痫的风险明显高于对照组(p < 0.0

1型糖尿病显然已成为全球性的重大公共卫生问题,1型糖尿病可能会伴随潜在的神经并发症。有研究表明1型糖尿病癫痫之间存在相关性,但并没有进行更多的相关研究,本研究旨在评估在中国台湾1型糖尿病和癫痫之间的关系。

研究人员收纳了来自台湾全民健康保险研究数据库(NHIRD)2568名1型糖尿病患者的数据,并进行了回顾性队列分析。

与对照组相比,在1型糖尿病患者中患癫痫的风险明显高于对照组(p < 0.0001)。校正混杂因素,包括年龄、性别、既往癫痫、智力残疾后,1型糖尿病患者的癫痫风险比对照组高2.84倍(HR为2.84; 95% CI, 2.11- 3.83)。

研究表明,1型糖尿病患者患癫痫的风险增加。1型糖尿病代谢异常,如高血糖和低血糖,可能对中枢神经系统产生破坏性影响,存在长期显著的神经系统后遗症,但是1型糖尿病与癫痫风险增加之间的致病因素尚需进一步的调查。

原始出处

Chou IC1,2, Wang CH1,3,4, Lin WD5,6, Tsai FJ1,3,5,7,8, Lin CC4,9, Kao CH10,11.Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study.Diabetologia. 2016 Mar 31

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    2016-04-14 李继凯

    文章不错

    0

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    2016-04-14 李继凯

    值得关注

    0

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    2016-04-08 1de3b290m83(暂无匿称)

    有趣

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1637308, encodeId=6299163e3088f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 10 08:45:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759657, encodeId=3c191e59657b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Sep 29 00:45:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78301, encodeId=d4ece830138, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:56:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78302, encodeId=c949e8302be, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:56:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76460, encodeId=46efe6460d5, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Fri Apr 08 19:58:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76309, encodeId=a814e6309d9, content=中国中午有相关报道了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160307/IMG56DD346053F0D5538.jpg, createdBy=7bed1697174, createdName=那夏花开, createdTime=Thu Apr 07 17:39:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76271, encodeId=0e8de6271be, content=疾病间可相互影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Thu Apr 07 14:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=)]
    2016-04-07 那夏花开

    中国中午有相关报道了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1637308, encodeId=6299163e3088f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 10 08:45:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759657, encodeId=3c191e59657b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Sep 29 00:45:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78301, encodeId=d4ece830138, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:56:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78302, encodeId=c949e8302be, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:56:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76460, encodeId=46efe6460d5, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Fri Apr 08 19:58:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76309, encodeId=a814e6309d9, content=中国中午有相关报道了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160307/IMG56DD346053F0D5538.jpg, createdBy=7bed1697174, createdName=那夏花开, createdTime=Thu Apr 07 17:39:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76271, encodeId=0e8de6271be, content=疾病间可相互影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Thu Apr 07 14:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=)]
    2016-04-07 Lisa971

    疾病间可相互影响。

    0

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