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J Dent Res：FGF8信号可以改变硬腭成骨细胞的最终命运

2018-01-28 lishiting MedSci原创

FGF8腭发育
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成纤维细胞生长因子(FGF)信号被认为参与调控了膜内及软骨内成骨过程中的骨发生。在腭发育过程中，硬腭前部的形成是通过颅神经嵴(CNC)来源的间充质细胞直接分化所得，但是在发育过程中调控成骨细胞命运的信号因子依旧不甚了解。这篇研究的目的是为了评估FGF信号决定腭间充质细胞成骨分化命运的潜在作用。

成纤维细胞生长因子(FGF)信号被认为参与调控了膜内及软骨内成骨过程中的骨发生。在腭发育过程中，硬腭前部的形成是通过颅神经嵴(CNC)来源的间充质细胞直接分化所得，但是在发育过程中调控成骨细胞命运的信号因子依旧不甚了解。这篇研究的目的是为了评估FGF信号决定腭间充质细胞成骨分化命运的潜在作用。研究通过在前腭敲入Shox2Cre和R26RFgf8等位基因可以局部激活FGF8信号，导致一种罕见的腭缺损：上颌骨完全缺失腭突并且在前腭形成异位软骨组织。这种异常的发育过程伴随着显著上调的细胞增殖，导致本该正常发育上颌骨腭突的部位异常腭组织增厚，并引起Osterix表达的完全抑制，进而导致骨形成的缺失。在异位软骨组织中，Runx2先与Sox9共表达，随后与Col II共表达的结果表明，成骨分化的命运向软骨形成方向发生转变。RNA测序分析得出与这种罕见的腭表型相一致的结果，增强的FGF8信号会下调与骨化、生物矿化组织发育和骨矿化相关基因的表达，但会上调与细胞增殖、软骨形成和决定细胞命运相关基因的表达，研究进一步通过实时反转录聚合酶链式反应验证了所选基因的表达情况。结论：这篇研究表明，FGF8信号作为

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    2018-02-04 1217549fm29暂无昵称

    henhao

    0

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    2018-02-04 121787d8m08暂无昵称

    henhao

    0

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    2018-01-30 zhaojie88

    #成骨#

    0

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    2018-01-30 jj000004

    #骨细胞#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=285104, encodeId=e74828510411, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Sun Feb 04 17:36:30 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285103, encodeId=2bd028510338, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7aed2257393, createdName=121787d8m08暂无昵称, createdTime=Sun Feb 04 17:34:25 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351656, encodeId=d10613516564f, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495030, encodeId=2c3f149503032, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283137, encodeId=b0ca28313e90, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Mon Jan 29 09:23:59 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282951, encodeId=cde228295180, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e61e2256333, createdName=1217558dm72暂无昵称, createdTime=Sun Jan 28 19:53:44 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282944, encodeId=105f282944c9, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 28 19:02:45 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282939, encodeId=f3a728293909, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Sun Jan 28 18:15:55 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 numb6

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=285104, encodeId=e74828510411, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Sun Feb 04 17:36:30 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285103, encodeId=2bd028510338, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7aed2257393, createdName=121787d8m08暂无昵称, createdTime=Sun Feb 04 17:34:25 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351656, encodeId=d10613516564f, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495030, encodeId=2c3f149503032, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283137, encodeId=b0ca28313e90, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Mon Jan 29 09:23:59 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282951, encodeId=cde228295180, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e61e2256333, createdName=1217558dm72暂无昵称, createdTime=Sun Jan 28 19:53:44 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282944, encodeId=105f282944c9, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 28 19:02:45 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282939, encodeId=f3a728293909, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Sun Jan 28 18:15:55 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 1217558dm72暂无昵称

    henhao

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=285104, encodeId=e74828510411, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Sun Feb 04 17:36:30 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285103, encodeId=2bd028510338, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7aed2257393, createdName=121787d8m08暂无昵称, createdTime=Sun Feb 04 17:34:25 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351656, encodeId=d10613516564f, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495030, encodeId=2c3f149503032, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283137, encodeId=b0ca28313e90, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Mon Jan 29 09:23:59 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282951, encodeId=cde228295180, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e61e2256333, createdName=1217558dm72暂无昵称, createdTime=Sun Jan 28 19:53:44 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282944, encodeId=105f282944c9, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 28 19:02:45 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282939, encodeId=f3a728293909, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Sun Jan 28 18:15:55 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 Y—xianghai

    学习了新知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=285104, encodeId=e74828510411, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Sun Feb 04 17:36:30 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285103, encodeId=2bd028510338, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7aed2257393, createdName=121787d8m08暂无昵称, createdTime=Sun Feb 04 17:34:25 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351656, encodeId=d10613516564f, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495030, encodeId=2c3f149503032, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Tue Jan 30 08:37:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283137, encodeId=b0ca28313e90, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Mon Jan 29 09:23:59 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282951, encodeId=cde228295180, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e61e2256333, createdName=1217558dm72暂无昵称, createdTime=Sun Jan 28 19:53:44 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282944, encodeId=105f282944c9, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 28 19:02:45 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282939, encodeId=f3a728293909, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/21/e2ec83e73d7f10bb0cba9f8cb35ce200.jpg, createdBy=10491728485, createdName=numb6, createdTime=Sun Jan 28 18:15:55 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 numb6

    厉害

    0