J Anesth:七氟烷麻醉诱导期间静脉麻醉药对QT间期的影响

2018-08-12 赵怀彪 罂粟花

已知七氟醚延长QT间期。本研究旨在确定静脉麻醉药和七氟醚的相互作用对QT间期的影响。

背景与目的:已知七氟醚延长QT间期。本研究旨在确定静脉麻醉药和七氟醚的相互作用对QT间期的影响。

方法:该研究包括48例接受腰椎手术的患者。 患者接受3μg/ kg芬太尼,然后在给予芬太尼注射后2分钟随机分配给T组,其中他们接受5mg / kg 硫戊巴比妥或P组,其中他们接受1.5mg / kg丙泊酚, 麻醉诱导。意识丧失后立即施用维库溴铵(1.5mg / kg)和七氟醚(3%吸入浓度)在,维库溴铵注射后3分钟进行气管插管。芬太尼使用前(T1)、芬太尼使用后2分钟(T2)、插管前即刻(T3)和插管后2分钟(T4),记录心率(HR),平均动脉压(MAP)、双频指数评分(BIS)和12导联心电图上记录的心率校正QT(QTc)。

结果:两组患者在基线患者特征方面无显着差异。两组麻醉诱导后BIS和MAP显着降低。 T3时,T组的MAP高于P组,两组HR降低。 T组在麻醉诱导后QTc间期延长,但在P组任何时间点均未改变。T组麻醉诱导后QTc间期长于P组。

结论:我们的结论是注射丙泊酚可以改善与七氟醚麻醉诱导相关的QTc间期延长。

原始出处:

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    2019-07-20 fusion
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    2018-08-15 苏小雨

    不错不错学习了

    0

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  7. 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    2018-08-14 xinmeili
  8. 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time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338306, encodeId=25763383066e, content=嗯嗯,学习学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Mon Aug 13 08:58:29 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338178, encodeId=8c023381e82b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 12 19:00:18 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2018-08-13 liumin1987

    嗯嗯,学习学习。

    0

  9. 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    2018-08-12 清风拂面

    谢谢分享学习

    0

相关资讯

BMC Anesthesiol:七氟烷与异丙酚-瑞芬太尼相比对老年冠心病患者心脏保护作用的随机对照研究

非心脏手术患者尤其是并存冠心病的老年患者,七氟醚的心脏保护作用仍存质疑。我们假设在非心脏手术中长时间吸入七氟烷可以改善患者的心肌损伤。

Life Sci:反复七氟烷暴露会损害老年雄性大鼠学习记忆功能

危重病患者有时需要反复的手术干预,因此确定反复接触麻醉剂对学习和记忆的影响是非常重要的。七氟烷是一种广泛使用的吸入性麻醉剂,几乎没有神经毒性,并且可以迅速恢复意识。但是七氟醚暴露的长期影响以及七氟醚重复暴露对认知功能的影响很少被报道,现有的研究相互矛盾。

Brain Res:不同剂量的七氟醚通过激活ERK通路和合成大鼠海马ARC蛋白来增强学习记忆功能

研究表明七氟烷可增强或减弱成年大鼠的记忆力。然而,这种双向效应的具体机制尚未明确。

Ja Clin Rep:与七氟烷麻醉相比,地氟醚麻醉使接受甲状腺手术的成年患者更易出现躁动

接受甲状腺手术的成年患者与地氟醚麻醉相比,地氟醚麻醉加剧了出现躁动,但并未影响拔管时间,术后疼痛或PONV。

Anesth Analg:原位肝移植的患者对七氟醚浓度需求更低

七氟烷是一种挥发性麻醉药,常用于行原位肝移植(OLT)术的终末期肝病(ESLD)患者的麻醉维持。越来越多的证据表明,与肝功能尚存的病人相比,终末期肝病患者对麻醉药物的需求量降低。挥发性麻醉药的效力以最小肺泡浓度(MAC)表示。在这项前瞻性盲研究中,我们对行腹部大手术肝功能正常患者和行OLD的ESLD患者的MAC值进行了比较。