综述:单核巨噬细胞亚型与动脉粥样硬化

2011-12-06 孙维粱,徐明江 CMBI

孙维粱,徐明江 北京大学医学部生理学与病理生理学系 摘要 临床上,巨噬细胞和泡沫细胞在动脉粥样硬化及其后遗症的发生发展过程中,功能繁多,作用广泛,提示我们在这其中不单单只有一种细胞亚型参与其中。巨噬细胞由单核细胞分化而来,在动脉粥样硬化斑块发生的炎症过程中,具有不同表型的单核巨噬细胞发挥着互补的作用,参与纤维帽和脂质核心的形成。 动脉粥样硬化发生过程中,不同亚型的单核细胞及巨噬细胞影

孙维粱,徐明江 北京大学医学部生理学与病理生理学系 摘要 临床上,巨噬细胞和泡沫细胞在动脉粥样硬化及其后遗症的发生发展过程中,功能繁多,作用广泛,提示我们在这其中不单单只有一种细胞亚型参与其中。巨噬细胞由单核细胞分化而来,在动脉粥样硬化斑块发生的炎症过程中,具有不同表型的单核巨噬细胞发挥着互补的作用,参与纤维帽和脂质核心的形成。 动脉粥样硬化发生过程中,不同亚型的单核细胞及巨噬细胞影响深远,意义重大。但在离体实验、动物实验和临床过程中,能否开发出众多细胞亚型的特异性标志物,对于细胞的分类鉴别至关重要。而后,在基因组学和药理学层面的改变或干预对于细胞亚型影响的明晰,可能对于阐明细胞结构,揭示细胞功能,继而开发行之有效的临床治疗方案大有裨益。 单核巨噬细胞在动脉粥样硬化斑块中的作用 单核细胞和巨噬细胞是临床动脉粥样硬化及其并发症发生的重要组成部分,是先天免疫和获得性免疫中必不可缺的一员。巨噬细胞由单核细胞分化而来,在炎症过程中,通过有效的吞噬,杀死入侵机体的异质抗原,移除细胞残片等方面发挥作用。在动脉粥样硬化及相关疾病中,巨噬细胞通过摄取修饰的低密度脂蛋白(Low density li

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  1. [GetPortalCommentsPageByObjectIdResponse(id=75043, encodeId=126ee50431a, content=正需要此类综述,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=225a1697989, createdName=1de7460am01(暂无匿称), createdTime=Thu Mar 31 18:32:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944320, encodeId=d48a1944320d7, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Wed Oct 31 19:16:00 CST 2012, time=2012-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3863, encodeId=62d43863bb, content=如果能让下载,那样更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:20:00 CST 2012, time=2012-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3862, encodeId=32e238624e, content=非常宝贵的资料,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:16:00 CST 2012, time=2012-01-01, status=1, ipAttribution=)]
    2016-03-31 1de7460am01(暂无匿称)

    正需要此类综述,赞一个!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=75043, encodeId=126ee50431a, content=正需要此类综述,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=225a1697989, createdName=1de7460am01(暂无匿称), createdTime=Thu Mar 31 18:32:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944320, encodeId=d48a1944320d7, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Wed Oct 31 19:16:00 CST 2012, time=2012-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3863, encodeId=62d43863bb, content=如果能让下载,那样更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:20:00 CST 2012, time=2012-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3862, encodeId=32e238624e, content=非常宝贵的资料,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:16:00 CST 2012, time=2012-01-01, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=75043, encodeId=126ee50431a, content=正需要此类综述,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=225a1697989, createdName=1de7460am01(暂无匿称), createdTime=Thu Mar 31 18:32:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944320, encodeId=d48a1944320d7, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Wed Oct 31 19:16:00 CST 2012, time=2012-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3863, encodeId=62d43863bb, content=如果能让下载,那样更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:20:00 CST 2012, time=2012-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3862, encodeId=32e238624e, content=非常宝贵的资料,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:16:00 CST 2012, time=2012-01-01, status=1, ipAttribution=)]
    2012-01-01 wanzhaof2008

    如果能让下载,那样更好

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=75043, encodeId=126ee50431a, content=正需要此类综述,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=225a1697989, createdName=1de7460am01(暂无匿称), createdTime=Thu Mar 31 18:32:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944320, encodeId=d48a1944320d7, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Wed Oct 31 19:16:00 CST 2012, time=2012-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3863, encodeId=62d43863bb, content=如果能让下载,那样更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:20:00 CST 2012, time=2012-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3862, encodeId=32e238624e, content=非常宝贵的资料,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97c153401, createdName=wanzhaof2008, createdTime=Sun Jan 01 12:16:00 CST 2012, time=2012-01-01, status=1, ipAttribution=)]
    2012-01-01 wanzhaof2008

    非常宝贵的资料,谢谢

    0