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Front Microbiol：山奈酚可抑制金黄色葡萄球菌生物膜的形成

2018-04-15 MedSci MedSci原创

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在表面形成生物膜的能力使金黄色葡萄球菌成为植入式医疗器械感染的主要致病因子。本研究旨在探究一种生物膜抑制剂，可用来预防由金黄色葡萄球菌生物膜引起的感染的抗生素。本研究中，研究人员描述了山奈酚，一种具有抗生物膜活性的小分子，可抑制金黄色葡萄球菌生物膜的形成。结晶紫（CV）染色和荧光显微镜显示，64μg/ml山奈酚可抑制80％的生物膜形成。同时，最小抑菌浓度（MIC）和生长曲线结果表明，山奈酚对被测菌

在表面形成生物膜的能力使金黄色葡萄球菌成为植入式医疗器械感染的主要致病因子。本研究旨在探究一种生物膜抑制剂，可用来预防由金黄色葡萄球菌生物膜引起的感染的抗生素。

本研究中，研究人员描述了山奈酚，一种具有抗生物膜活性的小分子，可抑制金黄色葡萄球菌生物膜的形成。结晶紫（CV）染色和荧光显微镜显示，64μg/ml山奈酚可抑制80％的生物膜形成。同时，最小抑菌浓度（MIC）和生长曲线结果表明，山奈酚对被测菌株没有抗菌活性。纤维蛋白原结合测定显示，山奈酚抑制生物膜形成的主要附着阶段。此外，荧光共振能量转移（FRET）测定和定量实时逆转录聚合酶链式反应（qRT-PCR）分析显示，山奈酚可降低金黄色葡萄球菌分选酶A（SrtA）的活性和粘附相关基因的表达。

基于这些结果，山奈酚为开发新的抗生物膜药物提供了一个起点，可降低细菌耐药性的风险，从而预防金黄色葡萄球菌生物膜相关感染的发生。

原始出处：

Ming D, Wang D, et al., Kaempferol Inhibits the Primary Attachment Phase of Biofilm Formation in Staphylococcus aureus. Front Microbiol. 2017 Nov 15;8:2263. doi: 10.3389/fmicb.2017.02263. eCollection 2017.

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    2019-02-23 12498ebem31暂无昵称

    #Biol#

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    2018-04-17 xjy02

    #Micro#

    0

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    2019-01-22 jiafufeng@yaho

    #CRO#

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    2018-10-07 sunylz

    #Bio#

    0

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    2018-04-16 jambiya

    #金黄色葡萄球菌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1767423, encodeId=9a441e6742345, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Feb 23 15:36:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084378, encodeId=ae1320843e847, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Apr 17 00:36:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857623, encodeId=ba98185e6230c, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Tue Jan 22 20:36:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918034, encodeId=6f59191803454, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Oct 07 17:36:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305029, encodeId=79e1130502929, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Mon Apr 16 15:36:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596896, encodeId=f41515968966c, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Mon Apr 16 15:36:00 CST 2018, time=2018-04-16, status=1, ipAttribution=)]
    2018-04-16 手留余香

    #葡萄球菌#

    0