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Bmj：孕期精神-神经系统药物的使用与新生儿药物戒断

2017-08-04 zhangfan MedSci原创

精神-神经系统药物阿片类非阿片类戒断综合征
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孕期精神-神经系统药物的使用较为普遍且缺乏相应的安全数据。本次研究的结果表明非阿片类药物会进一步增加新生儿药物戒断的危险性和严重程度

近日研究人员评估了孕期服用抗精神药物和阿片类药物对新生儿药物戒断的发生率和严重程度的影响。

共201275名孕妇参与了本次研究，研究考察产妇孕期服用抗精神病类药物，特别是抗抑郁药、非典型抗精神病药，地西泮，加巴喷丁，非苯二氮类催眠药以及处方类阿片类药物情况。研究的主要终点是新生儿戒断症状诊断。

研究发现，单独服用处方类阿片药物，新生儿药物戒断绝对风险为1.0%，但阿片类药物与加巴喷丁共处方导致新生儿药物戒断绝对风险上升为11.4%。对于宫内暴露于处方阿片类药物的新生儿，接触其他药物的相对风险调整的倾向得分如下：抗抑郁药，1.34(95% CI 1.22-1.47)；苯二氮卓类1.49 (1.35- 1.63)；加巴喷丁，1.61 (1.26-2.06)；抗精神病药，1.20 (0.95 -1.51)；非苯二氮类催眠药1.01 (0.88 - 1.15)。在宫内接触两种或多种精神药物和阿片类药物时，戒断风险增加了2倍 (2.05， 1.77-2.37)。与阿片类药物单独相比，暴露于阿片类药物和精神药物的新生儿戒断症状严重程度增加。

孕期精神-神经系统药物的使用较为普遍且缺乏相应的安全数据。本次研究的结果表明非阿片类药物会进一步增加新生儿药物戒断的危险性和严重程度。

原始出处：


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1804252, encodeId=13ad180425271, content=<a href='/topic/show?id=6596e648041' target=_blank style='color:#2F92EE;'>#精神-神经系统药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76480, encryptionId=6596e648041, topicName=精神-神经系统药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Thu Nov 02 01:55:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231213, encodeId=206b23121332, content=学习了受益匪浅。., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 07 19:25:56 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283050, encodeId=68a51283050ed, content=<a href='/topic/show?id=4fade445192' target=_blank style='color:#2F92EE;'>#神经系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74451, encryptionId=4fade445192, topicName=神经系统)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Sat Aug 05 23:55:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230123, encodeId=cd152301230b, content=孕期用药，需谨慎, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sat Aug 05 00:56:53 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848365, encodeId=4785184836566, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jul 17 02:55:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230100, encodeId=769b230100ec, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 04 23:53:01 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-11-02 rebeccajiejie

    #精神-神经系统药物#

    0

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    2017-08-07 虈亣靌

    学习了受益匪浅。.

    0

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    2017-08-05 luoxiaog

    #神经系统#

    0

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    2017-08-05 QQ25ed180f

    孕期用药，需谨慎

    0

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    2018-07-17 gaoxiaoe

    #BMJ#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1804252, encodeId=13ad180425271, content=<a href='/topic/show?id=6596e648041' target=_blank style='color:#2F92EE;'>#精神-神经系统药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76480, encryptionId=6596e648041, topicName=精神-神经系统药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Thu Nov 02 01:55:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231213, encodeId=206b23121332, content=学习了受益匪浅。., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 07 19:25:56 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283050, encodeId=68a51283050ed, content=<a href='/topic/show?id=4fade445192' target=_blank style='color:#2F92EE;'>#神经系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74451, encryptionId=4fade445192, topicName=神经系统)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Sat Aug 05 23:55:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230123, encodeId=cd152301230b, content=孕期用药，需谨慎, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sat Aug 05 00:56:53 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848365, encodeId=4785184836566, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jul 17 02:55:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230100, encodeId=769b230100ec, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 04 23:53:01 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-04 虈亣靌

    不错的，学习了！谢谢分享！

    0