J Clin Virol:对新出现的重组人腺病毒引起的流行性角膜结膜炎治疗现状

2019-01-20 MedSci MedSci原创

日本北海道大学人兽共患病控制研究中心生物信息学研究室的Gonzalez G和日本九州大学眼科的Yawata N等人近日在J Clin Virol杂志上发表了一篇综述文章,作者系统的总结了腺病毒流行性角膜结膜炎(EKC)的临床材料,并对新出现的重组人腺病毒的诊断和治疗进行了讨论。

日本北海道大学人兽共患病控制研究中心生物信息学研究室的Gonzalez G和日本九州大学眼科的Yawata N等人近日在J Clin Virol杂志上发表了一篇综述文章,作者系统的总结了腺病毒流行性角膜结膜炎(EKC)的临床材料,并对新出现的重组人腺病毒的诊断和治疗进行了讨论。

腺病毒流行性角膜结膜炎(EKC)表现为严重的结膜炎症状,可导致角膜混浊和视力模糊,并持续数月。EKC具有高度传染性,因此必须进行准确诊断和快速控制。 EKC可以由人腺病毒D(HAdV-D)中的许多亚型引起:8,37和64(以前称为19a),并且这些类型被认为是EKC传播超过50年至今还没有消灭的主要原因。尽管如此,最近改进的分子分型方法已经鉴定出重组HAdV-D类型53,54和56,这是全世界新出现的EKC感染的病原体。由于这些重组类型可能导致EKC病例没有进行诊断或被低估,可能会作为新的EKC爆发的来源。循环系统中HAdV-D类型中的重组事件代表了新的传染病威胁的来源。此外,越来越多的腺病毒类型的发现,可以使研究人员进行基因组学和表型上的比较,以确定与EKC相关的病理学特性。

这篇综述涵盖了EKC的临床特征、临床实践中的当前挑战以及与EKC相关的HAdV研究的最新进展,该研究侧重于开发新的诊断和治疗方法。

原文出处:

Gonzalez, G., et al., Challenges in management of epidemic keratoconjunctivitis with emerging recombinant human adenoviruses. J Clin Virol, 2019. 112: p. 1-9.

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    2019-12-10 tulenzi
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    2019-01-23 清风拂面

    谢谢分享学习

    0

  9. 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    2019-01-22 snowpeakxu
  10. 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    2019-01-21 飛歌

    学习了很有用不错

    0