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经皮超选择性肾上腺动脉栓塞治疗原发性醛固酮增多症有效可行

2013-08-02 晓静 摘编 cmt

经皮超选择性肾上腺动脉栓塞原发性醛固酮增多症
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董徽、蒋雄京和关婷等评估了经皮超选择性肾上腺动脉栓塞(SAAE)治疗原发性醛固酮增多症(PA)的安全性和有效性，结果发现，SAAE治疗PA有效、可行，但因样本量小，仍需进一步研究验证。相关论文发表于2013年第6期《中华高血压杂志》。 研究入选了行SAAE治疗的PA患者10例(7例醛固酮腺瘤、2例双侧肾上腺增生和1例单侧肾上腺增生)。术后随访血压、降压药使用、血浆肾素活性、血浆醛固酮、血钾水平的

董徽、蒋雄京和关婷等评估了经皮超选择性肾上腺动脉栓塞(SAAE)治疗原发性醛固酮增多症(PA)的安全性和有效性，结果发现，SAAE治疗PA有效、可行，但因样本量小，仍需进一步研究验证。相关论文发表于2013年第6期《中华高血压杂志》。

研究入选了行SAAE治疗的PA患者10例(7例醛固酮腺瘤、2例双侧肾上腺增生和1例单侧肾上腺增生)。术后随访血压、降压药使用、血浆肾素活性、血浆醛固酮、血钾水平的变化和不良事件的发生情况。

结果年龄28～51(40±8)岁的患者10例，其中SAAE技术上成功9例(90%)，因肾上腺下动脉的起源异常未成功1例。与术前相比，9例SAAE成功患者术后6月的诊室血压、24 h平均血压及使用降压药种类均降低[分别(132.7±7.7)/(82.3±5.3)比(148.7±7.7)/(88.9±6.5)mm Hg，(129.8±5.9)/(80.0±5.7)比(145.0±7.1)/(87.8±6.2)mm Hg，(1.6±0.7)比(3.4±0.5)种，均P<0.05]，普食立位醛固酮水平亦降低[(285.9±39.4)比(518.0±127.4)pmol/L，P<0.05]，而普食立位血浆肾素活性和血钾升高[分别(1.2±0.4)比(0.4±0.2)μg/(L·h)，(4.0±0.2)比(3.1±0.4)mmol/L，均P<0.05]。SAAE成功的9例患者中，7例治愈，2例双侧肾上腺增生患者改善，1例单侧肾上腺增生患者术后12月复发，行二次栓塞后治愈。1例醛固酮腺瘤患者因术中血压骤升出现高血压脑病，给予对症处理后完全恢复。围手术期和随访期间无其他严重不良事件发生。

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    2014-03-02 小几洁

    #动脉栓塞#

    0

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    2013-09-29 肉我只吃一口

    #选择性#

    0

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    2014-06-09 FukaiBao

    #醛固酮增多症#

    0

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    2014-06-25 xuyong523

    #肾上腺#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1973647, encodeId=ba7f19e36471c, content=<a href='/topic/show?id=208d33248a1' target=_blank style='color:#2F92EE;'>#动脉栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33248, encryptionId=208d33248a1, topicName=动脉栓塞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sun Mar 02 08:46:00 CST 2014, time=2014-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922844, encodeId=95c6192284463, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Sep 29 01:46:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080052, encodeId=3088208005257, content=<a href='/topic/show?id=5efa956449d' target=_blank style='color:#2F92EE;'>#醛固酮增多症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95644, encryptionId=5efa956449d, topicName=醛固酮增多症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Mon Jun 09 09:46:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895043, encodeId=81681895043a1, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Wed Jun 25 13:46:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1846450, encodeId=25dc1846450e0, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Tue Oct 01 09:46:00 CST 2013, time=2013-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379201, encodeId=9a2a13e9201af, content=<a href='/topic/show?id=ac549564240' target=_blank style='color:#2F92EE;'>#醛固酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95642, encryptionId=ac549564240, topicName=醛固酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sun Aug 04 06:46:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]
    2013-10-01 jiyangfei

    #原发性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1973647, encodeId=ba7f19e36471c, content=<a href='/topic/show?id=208d33248a1' target=_blank style='color:#2F92EE;'>#动脉栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33248, encryptionId=208d33248a1, topicName=动脉栓塞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sun Mar 02 08:46:00 CST 2014, time=2014-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922844, encodeId=95c6192284463, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Sep 29 01:46:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080052, encodeId=3088208005257, content=<a href='/topic/show?id=5efa956449d' target=_blank style='color:#2F92EE;'>#醛固酮增多症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95644, encryptionId=5efa956449d, topicName=醛固酮增多症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Mon Jun 09 09:46:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895043, encodeId=81681895043a1, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Wed Jun 25 13:46:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1846450, encodeId=25dc1846450e0, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Tue Oct 01 09:46:00 CST 2013, time=2013-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379201, encodeId=9a2a13e9201af, content=<a href='/topic/show?id=ac549564240' target=_blank style='color:#2F92EE;'>#醛固酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95642, encryptionId=ac549564240, topicName=醛固酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sun Aug 04 06:46:00 CST 2013, time=2013-08-04, status=1, ipAttribution=)]
    2013-08-04 cmsvly

    #醛固酮#

    0