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Movement Disorder:颈肌张力障碍患者的齿状核丘脑束的显微结构异常

2021-06-28 MedSci原创 MedSci原创

颈肌张力障碍齿状核丘脑束
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DTI指标的显著降低提示CD的DRTT内存在显微结构异常，其特征是与轴突完整性下降一致的纤维示踪模式。

结构和功能成像研究支持成人特发性肌张力障碍的广泛连接性异常，包括颈肌张力障碍（CD），其是涉及基底节、运动和感觉皮质、丘脑和脑干核及相关中继的网络障碍，以及小脑。小鼠模型显示异常小脑核活动与肌张力障碍样姿势异常相关，从而激发了人们对小脑流出对肌张力障碍的贡献的兴趣。此外，特发性肌张力障碍患者小脑输出功能障碍的证据来源于眼球链接减少的经典条件和依赖于感觉加工和感觉运动整合的运动输出的异常预测。在特发性颈肌张力障碍(CD)中，齿状突丘脑束(DRTT)的研究仍然很少，尽管有证据表明该通路与疾病的病理生理学有关。 了解小脑输出通路的异常程度及其与CD临床特征的关系有助于提高对肌张力障碍的解剖学标志的认识，并为小脑输出通路的神经调节靶向性提供信息。Davide Martino等使用DTI 示踪成像来表征CD患者和年龄和性别匹配的对照受试者的DRTT，并观察显示与CD相关的轴突完整性降低的显微结构敏感性改变。研究成果发表在Movement Disorders杂志。 应用弥散张量成像(DTI)检查CD患者的DRTT。收集67例受试者的磁共振成像扫描，使用基于二进制Trotography的DRTT模板

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    2021-08-07 cmsvly

    #Disord#

    0

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    2021-09-01 heli0118

    #微结构#

    0

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    2022-03-01 cmj8wellington

    #Dis#

    0

  4. 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encryptionId=67cc600242, topicName=disorder)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Wed Oct 13 04:42:57 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049736, encodeId=44ae2049e360c, content=<a href='/topic/show?id=92751035606b' target=_blank style='color:#2F92EE;'>#齿状核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103560, encryptionId=92751035606b, topicName=齿状核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sat Jan 08 20:42:57 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774785, encodeId=99e31e74785d0, content=<a href='/topic/show?id=aa9c499213d' target=_blank style='color:#2F92EE;'>#张力#</a>, beContent=null, 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authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564345, encodeId=bb1915643455c, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2021-10-13 12498cbcm00(暂无昵称)

    #disorder#

    0

  5. 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authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564345, encodeId=bb1915643455c, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2022-01-08 lingaifan

    #齿状核#

    0

  6. 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    2021-12-04 zhmscau

    #张力#

    0

  7. 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2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540595, encodeId=df79154059536, content=<a href='/topic/show?id=fa348091883' target=_blank style='color:#2F92EE;'>#肌张力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80918, encryptionId=fa348091883, topicName=肌张力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=524213265654, createdName=gujh, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558336, encodeId=d1b415583369a, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564345, encodeId=bb1915643455c, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2021-06-30 zhouqu_8

    #肌张力障碍#

    0

  8. 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2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540595, encodeId=df79154059536, content=<a href='/topic/show?id=fa348091883' target=_blank style='color:#2F92EE;'>#肌张力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80918, encryptionId=fa348091883, topicName=肌张力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=524213265654, createdName=gujh, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558336, encodeId=d1b415583369a, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564345, encodeId=bb1915643455c, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2021-06-30 gujh

    #肌张力#

    0

  9. 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    2021-06-30 xlwang2696

    #丘脑#

    0

  10. 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authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564345, encodeId=bb1915643455c, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Jun 30 08:42:57 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2021-06-30 xlwang2696

    #丘脑#

    0

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