Cochrane Database Syst Rev:降低钠摄入能否改善健康?

2017-05-04 梁舒瑶;常路 环球医学

2017年4月,发表在《Cochrane Database Syst Rev》的一项研究调查了低钠饮食vs高钠饮食对血压、肾素、醛固酮、儿茶酚胺、胆固醇和甘油三酯的影响。

2017年4月,发表在《Cochrane Database Syst Rev》的一项研究调查了低钠饮食vs高钠饮食对血压、肾素、醛固酮、儿茶酚胺、胆固醇和甘油三酯的影响。

背景:尽管已经调查了超过100年,但是降低钠的摄入是否会改善健康的问题仍未解决。

目的:旨在评估低钠摄入vs高钠摄入对收缩压和舒张压(SBP和DBP)、肾素、醛固酮、儿茶酚胺、胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯等的血浆或血清水平的影响。

主要结果:总共纳入了185项研究。平均钠摄入从201mmol/d(相当于较高的常规水平)降低到66mmol/d(相当于推荐水平)。钠摄入的降低对血压的影响如下:

血压正常的白人:SBP:平均差(MD),-1.09mmHg(95% CI,-1.63~-0.56;P=0.0001);89项研究,8569名参与者;DBP:+0.03mmHg(MD,95% CI,-0.37~0.43;P=0.89);90项研究,8833名参与者。高质量证据。

血压正常的黑人:SBP:MD,-4.02mmHg(95% CI,-7.37~-0.68;P=0.002);7项研究,506名参与者;DBP:MD,-2.01mmHg(95% CI,-4.37~0.35;P=0.09);7项研究,506名参与者。中等质量证据。

血压正常的亚洲人:SBP:MD,-0.72mmHg(95% CI,-3.86~2.41;P=0.65);DBP:MD,-1.63mmHg(95% CI,-3.35~0.08;P=0.06);3项研究,393名参与者。中等质量证据。

高血压白人:SBP:MD,-5.51mmHg(95% CI,-6.45~-4.57;P<0.00001);84项研究,5925名参与者;DBP:MD,-2.88mmHg(95% CI,-3.44~-2.32;P<0.00001);85项研究,6001名参与者。高质量证据。

高血压黑人:SBP:MD,-6.64mmHg(95% CI,-9.00~-4.27;P=0.00001);8项研究,619名参与者;DBP:-2.91mmHg(95% CI,-4.52~-1.30;P=0.0004);8项研究,619名参与者。中等质量证据。

高血压亚洲人:SBP:MD,-7.75mmHg(95% CI,-11.44~-4.07;P<0.0001);9项研究,501名参与者;DBP:MD,-2.68mmHg(95% CI,-4.21~-1.15;P=0.0006)。中等质量证据。

血浆或血清中,与高钠摄入相比,低钠摄入者的肾素(P<0.00001)、醛固酮(P<0.00001)、去甲肾上腺素(P<0.00001)、肾上腺素(P<0.03)、胆固醇(P<0.0005)和甘油三酯(P<0.0006)水平显着性增加。在钠摄入低于250mmol/d和减钠干预至少1周的125个研究人群中,所有这些影响都稳定。

原始出处:

Graudal NA, et al. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev. 2017 Apr 9;4:CD004022. doi: 10.1002/14651858.CD004022.pub4.

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    2017-05-22 flysky120

    学习一下知识

    0

  4. 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time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193783, encodeId=5d1a193e83fa, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 04 18:26:54 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193768, encodeId=331b193e68cb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-14 flysky120

    学习一下知识了

    0

  5. 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time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193783, encodeId=5d1a193e83fa, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 04 18:26:54 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193768, encodeId=331b193e68cb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-06 bbjsj_1981
  6. 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createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
  7. 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time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193783, encodeId=5d1a193e83fa, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 04 18:26:54 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193768, encodeId=331b193e68cb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-06 1e0f8808m18(暂无匿称)

    高钠危害健康。

    0

  8. 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time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193783, encodeId=5d1a193e83fa, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 04 18:26:54 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193768, encodeId=331b193e68cb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 1e0f8808m18(暂无匿称)

    学习了,降低钠摄入有利健康。

    0

  9. 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time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193783, encodeId=5d1a193e83fa, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 04 18:26:54 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193768, encodeId=331b193e68cb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 虈亣靌

    好好学习,涨知识

    0

  10. 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createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu May 04 17:54:16 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 明月清辉

    谢谢分享,学习了

    0