JAHA:早发缺血性卒中的危险因素

2018-10-24 xing.T MedSci原创

由此可见,该研究确定了11种血管危险因素与早发性IS之间存在关联,其中心房颤动、心血管疾病以及1型和2型糖尿病显示出尤为强烈的相关性。

最近的研究表明年轻的缺血性卒中(IS)患者血管危险因素的患病率越来越高。然而,所有血管危险因素与早发性IS之间的关联强度尚未完全明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员将来自基于人群的队列研究(FINRISK)的961名在25至49岁期间首次发生IS的患者与1403名频率匹配的无卒中对照者进行了比较。评估的危险因素包括活动性恶性肿瘤、心房颤动、心血管疾病、目前吸烟状况、卒中家族史、高密度脂蛋白胆固醇、高甘油三酯、低密度脂蛋白胆固醇高血压、1型糖尿病和2型糖尿病。研究人员根据年龄、性别和IS病因进行了亚组分析。

在完全调整的多变量Logistic回归分析中,IS的显著危险因素包括心房颤动(比值比[OR]为10.43; 95%置信区间[CI]为2.33-46.77]、心血管疾病(OR为8.01; 95%CI为3.09-20.78)、1型糖尿病(OR为6.72; 95%CI为3.15-14.33)、2型糖尿病(OR为2.31; 95%CI为1.35-3.95)、低密度脂蛋白胆固醇(OR为1.81; 95%CI为1.37-2.40)、当前吸烟状况(OR为1.81; 95%CI为1.50-2.17)、高血压(OR为1.43; 95%CI为1.17-1.75)和卒中家族史(OR为1.37; 95%CI为1.04-1.82)。高密度脂蛋白胆固醇与IS呈负相关。在亚组分析中,目前吸烟状况和1型糖尿病的关联最为一致。

由此可见,该研究确定了11种血管危险因素与早发性IS之间存在关联,其中心房颤动、心血管疾病以及1型和2型糖尿病显示出尤为强烈的相关性。

原始出处:

Reetta Kivioja.et al. Risk Factors for Early‐Onset Ischemic Stroke: A Case‐Control Study.JAHA.2018. https://www.ahajournals.org/doi/10.1161/JAHA.118.009774

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    2018-10-26 zhaohui6731
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    2018-10-25 jyzxjiangqin

    早发缺血性卒中。

    0

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    2018-10-24 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2018-10-24 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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    2018-10-24 183****7028

    学习

    0

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