EJCN: 姜黄素对非酒精性脂肪性肝病患者肝脏代谢的影响

2019-01-20 MedSci MedSci原创

非酒精性脂肪性肝病(NAFLD)是一个重要的全球健康问题。这些患者中最常见的死因是心血管疾病。本研究的目的是探究补充姜黄素对NAFLD患者心血管危险因素的影响。

背景
非酒精性脂肪性肝病(NAFLD)是一个重要的全球健康问题。这些患者中最常见的死因是血管疾病。本研究的目的是探究补充姜黄素对NAFLD患者血管危险因素的影响。

方法和材料
在这项随机对照的临床试验中,52名NAFLD患者被随机分配至接受生活方式建议加1500 mg姜黄素治疗12周或安慰剂治疗12周。在研究开始和结束时测量人体测量指数,血脂谱,胰岛素抵抗以及肝脂肪变性和纤维化评分,并在组内和组间进行比较。

结果
在姜黄素治疗组中患者肝纤维化,血清胆固醇,葡萄糖和丙氨酸氨基转移酶(ALT)显着降低(p <0.05)。两组人体测量指数,血脂,胰岛素抵抗和肝脂肪变性均显着下降(p <0.05)。

结论
我们的研究结果显示,每日摄入1500毫克姜黄素加减肥并不比单独减肥更能改善NAFLD患者的心血管危险因素。需要进一步研究不同剂量的姜黄素对于肝脏代谢的影响。

原始出处:

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    2019-03-19 qjddjq
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