Diabetes Care:1型糖尿病患者脑血管病的临床和MRI特征

2018-12-16 xing.T MedSci原创

由此可见,与健康对照者相比,脑部SVD,特别是CMBs,在1型糖尿病的年轻人中更为常见。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在评估与健康对照受试者相比,1型糖尿病患者发生脑小血管疾病(SVD)的患病率,并归纳与SVD相关的糖尿病相关因素。

该亚组研究为横断面研究,纳入了191名患有1型糖尿病且中位年龄为40.0岁(四分位数范围33.0-45.1)以及30名健康的且年龄和性别匹配的对照受试者。所有参与者都接受了临床调查和脑部MRI检查,以评估大脑SVD。

1型糖尿病患者的脑部SVD比健康对照者更为常见:任何病理标记为35 vs. 10%(P=0.005),脑微出血(CMBs)为24 vs. 3.3%(P=0.008),白质高信号为 17 vs. 6.7%(P=0.182),而腔隙为2.1 vs. 0%(P=1.000)。CMB与收缩压独立相关(比值比为1.03[95%置信区间为1.00-1.05],P=0.035)。

由此可见,与健康对照者相比,脑部SVD,特别是CMBs,在1型糖尿病的年轻人中更为常见。

原始出处:

Lena M. Thorn,et al. Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes.Diabetes Care.2018.https://doi.org/10.2337/dc18-1302

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    2019-06-26 hb2008ye
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    2018-12-16 misszhang

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