Clinica Chimica Acta:离子间隙参考区间与仪器相关,与白蛋白水平相关性较弱

2020-03-01 MedSci MedSci原创

阴离子间隙(AG)有助于酸碱紊乱的鉴别诊断。由于新的分析方法的陆续出现,该检测方法的价值降低了。我们的目标是比较不同设备和东南亚人群的AG参考区间。 我们在三家医院研究了AG。一台使用了cobas 8000; 另外两个是Architect c16000。 我们纳入了≥18岁的连续成年人,将他们样本送去检查电解质和肌酐。 我们对所有患者和电解质正常的患者进行了AG评估。。 研究结果显示

阴离子间隙(AG)有助于酸碱紊乱的鉴别诊断。由于新的分析方法的陆续出现,该检测方法的价值降低了。我们的目标是比较不同设备和东南亚人群的AG参考区间。

我们在三家医院研究了AG。一台使用了cobas 8000; 另外两个是Architect c16000。 我们纳入了≥18岁的连续成年人,将他们样本送去检查电解质和肌酐。 我们对所有患者和电解质正常的患者进行了AG评估。。

研究结果显示,三家医院对所有患者和正常电解质亚组的AG均值有明显差异(P <0.001)。所有患者的AG参考间隔分别为9-195-155-15 5mmol / L,而正常电解质亚组的AG参考间隔分别为10-176-145-12 mmol / L。与正常白蛋白组相比,两家医院的低白蛋白血症患者的AG较低(P <0.001P = 0.03),而三家医院的高白蛋白血症患者的AG较高(P <0.001)。。

研究结果表明,不同的仪器产生不同的AGs。白蛋白水平与AG之间存在微弱的相关性。实验室应验证检测实验室错误时使用的参考区间,并协助临床医生对酸碱紊乱和其他疾病进行鉴别诊断

原始出处:

Busadee Pratumvinit,Leslie Lam,Anion gap reference intervals show instrument dependence and weak correlation with albumin levels

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    2020-09-13 windight
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    2020-03-03 珙桐
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